Lck, Human, 重组蛋白 (His),Lck Protein, Human, Recombinant (His)

Lck, Human, 重组蛋白 (His)|TMPH-02275|TargetMol

价格	￥11700
包装	1mg

最小起订量	1mg
发货地	上海
更新日期	2026-05-09

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产品详情

中文名称:Lck, Human, 重组蛋白 (His)	英文名称:Lck Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	纯度规格: 90.00%
产品类别: 抑制剂
种属: Human	表达系统: E. coli
蛋白长度: 1-539 aa	标签: N-6xHis
货号: T011\|TMPH-02275

Product Introduction

Bioactivity

名称	Lck Protein, Human, Recombinant (His)
描述	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2.
存储条件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	Protein YT 16 \| LSK

关键字： Tyrosine-protein kinase Lck;T cell-specific protein-tyrosine kinase;Proto-oncogene Lck;Protein YT16;p56-LCK;Lymphocyte cell-specific protein-tyrosine kinase;Leukocyte C-terminal Src kinase (LSK);LCK;TargetMol

公司简介

成立日期	2013-04-18 （14年）	注册资本	589.8595万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生物化工,化学试剂,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol 中国（陶术生物）

VIP 1年

公司成立：14年
注册资本：589.8595万人民币
企业类型：股份有限公司(非上市、自然人投资或控股)
主营产品：活性分子、生化试剂、天然产物、重组蛋白、抗体相关、试剂盒、药物筛选化合物库、技术服务
公司地址：静安区江场三路238号8楼

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Lck, Human, 重组蛋白 (His)|TMPH-02275|TargetMol相关厂家报价

产品名称	价格		公司名称	报价日期
重组人LCK蛋白	询价	VIP4年	维百奥（北京）生物科技有限公司	2026-03-12
重组Human DSG3 蛋白, C-His	￥1588	VIP2年	普健生物（武汉）科技有限公司	2026-05-18
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