化合物 12-Nitrolinoleate|T207754|TargetMol

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包装	50mg	10mg

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中文名称:化合物 12-Nitrolinoleate	英文名称:12-Nitrolinoleate
CAS:774603-05-3	品牌: TargetMol
产地: 美国	保存条件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
产品类别: 抑制剂
货号: T207754

名称	12-Nitrolinoleate
描述	12-Nitrolinoleate is a linoleic acid derivative that acts as an agonist of peroxisome proliferator-activated receptor γ (PPARγ). Formed via exposure to acidified nitrite, it is present in human red blood cells and plasma. This compound stimulates PPARγ-dependent gene expression, demonstrated in a reporter assay with MCF-7 cells expressing human PPARγ, with an EC50 of 0.045 µM. At 2.5 µM, 12-Nitrolinoleate reduces the secretion of IL-6, TNF-α, and chemokine (C-C motif) ligand 2 (CCL2) in THP-1 and RAW 264.7 macrophages, and it suppresses LPS-induced NF-κB transcriptional activity in RAW 264.7 macrophages. Additionally, it inhibits TNF-α-induced increases in vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) and enhances heme oxygenase-1 (HO-1) levels in primary human aortic endothelial cells at concentrations of 1, 5, or 10 µM.
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
相关产品	Rhamnose monohydrate \| D-Psicose \| Kaolin \| Magnesium acetate tetrahydrate \| Daidzein \| Gum arabic \| Gluconate Calcium \| 1,8-Cineole \| Kojic acid \| D(+)-Raffinose pentahydrate \| Ethyl linoleate \| Hydroxypropyl Cellulose

关键字： 12-LNO2 | 12-NO2-LA | 12-nitro-9,12-Octadecadienoic Acid|TargetMol

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