| 名称 | PACAP-38 (31-38), human, mouse, rat acetate |
| 描述 | PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can |
| 体外活性 | PACAP-38 (31-38), human, mouse, rat acetate 在不同条件下展示了其对细胞活性的影响。在(0.01-10 nM; HEK 293 cells)条件下，通过cAMP积累和胞质游离钙增加促进神经细胞表达内源性PAC1受体，并以剂量依赖的方式增加细胞内Ca2+浓度，EC50值为0.81 nM。在(300 nM; 4 h)条件下，促进神经细胞生成APPsα[1]。在(0.01 nM; 48 h)条件下，强效且有效地刺激SCG神经文化中NPY的分泌[2]。在(100 nM; 14 d)条件下，产生持续的NPY和儿茶酚胺分泌[2]。在(100 nM; 2 min; NCI-H838 cells)和(100 nM; 30 min; NCI-H838 cells)条件下，分别诱导了EGFR、HER2和ERK酪氨酸磷酸化和EGFR酪氨酸磷酸化，后者还增加了ROS水平51%[3]。在(10 nM; 48 h)条件下，刺激NCI-H838细胞增长。这些结果展示了PACAP-38 (31-38), human, mouse, rat acetate 在多种细胞活性调节中的作用。 |
| 存储条件 | Keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 20 mg/mL (17.82 mM), Sonication is recommended.
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| 关键字 | PACAP-38 , human, mouse, rat Acetate | PACAP38 (3138), human, mouse, rat acetate | PACAP 38 (31 38), human, mouse, rat acetate |
| 相关产品 | PACAP (1-27), human, ovine, rat TFA | PACAP 1-38 acetate | Thielocin B1 | PACAP (6-38), human, ovine, rat acetate | PACAP (1-38), human, ovine, rat TFA | PACAP (1-27), human, ovine, rat acetate | PA-8 | PACAP-38 (16-38), human, mouse, rat | PAC1R antagonist 1 | PACAP (1-38) | PACAP (1-38), human, ovine, rat | VIP(Guinea pig) |
| 相关库 | 经典已知活性库 | 已知活性化合物库 | 多肽分子库 | GPCR靶点分子库 | 膜蛋白靶向化合物库 |