OTUB1, Human, 重组蛋白 (His)|TMPY-02214|TargetMol

价格	￥2190
包装	100μg

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中文名称:OTUB1, Human, 重组蛋白 (His)	英文名称:OTUB1 Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	产品类别: 抑制剂
货号: TMPY-02214

名称	OTUB1 Protein, Human, Recombinant (His)
描述	Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytoplasm protein that belongs to the peptidase C65 family. OTUB1 is a hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128 / GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 of OTUB1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 of OTUB1 stabilizes RNF128 and promotes anergy. OTUB1 regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). OTUB1 mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. OTUB1 is also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
存储条件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	OTU-1 \| OTU 1 \| OTB-1 \| OTB 1 \| HSPC-263 \| HSPC 263

关键字： OTU1|||OTU deubiquitinase, ubiquitin aldehyde binding 1|||OTB1|||HSPC263|TargetMol

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产品名称	价格		公司名称	报价日期
卵巢肿瘤蛋白1(OTUB1)重组蛋白	￥2520	VIP7年	上海泽叶生物科技有限公司	2026-05-12
重组Human B2M 蛋白, C-His	￥1788	VIP2年	普健生物（武汉）科技有限公司	2026-05-12
Recombinant Human OTUB1 / OTB1 Protein (His tag)	￥1950	VIP4年	上海沪震实业有限公司	2026-05-12

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