Granzyme B/GZMB, Human, 重组蛋白 (His)|TMPY-00817|TargetMol

价格	￥697
包装	5μg

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中文名称:Granzyme B/GZMB, Human, 重组蛋白 (His)	英文名称:Granzyme B/GZMB Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	产品类别: 抑制剂
种属: Human	表达系统: HEK293 Cells
蛋白长度: A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Gly 19	标签: C-His
货号: T011\|TMPY-00817

名称	Granzyme B/GZMB Protein, Human, Recombinant (His)
描述	Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.
存储条件	Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	granzyme B \| CTSGL-1 \| CTSGL 1 \| CTLA-1 \| CTLA 1 \| CGL 1

关键字： SECT;HLP;granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1);CTSGL1;CTLA1;CSP-B;CSPB;CGL-1;CGL1;CCPI;TargetMol

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