Product Name：Ac-[Pro18, Asp21] β- Amyloid (17 - 21), amide, iAb5p Pro18 Asp21
CAS No.：339990-02-2
Synonyms：β-折叠破坏多肽
Catalog No.：107P115
Brand：Typeptide Biotech（肽研生物）
Description：Ac-[Pro18, Asp21] β- Amyloid (17 - 21), amide, iAb5p Pro18 Asp21是两端封闭的序列。Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide别名iAβ5p, Beta-sheet Breaker Peptide βiA 5p，是一个序列为Ac-LPFFD-NH2的五肽，它是一个带有可以增强其抗蛋白水解能力的化学修饰的多肽类似物。iAβ5p是一个β-折叠破坏多肽，并且跟大多数已知的可以被大脑选择性摄取的蛋白和多肽相比，iAβ5p穿过血脑屏障(BBB)的能力更强，因此可以假定其正在被特定的运输到大脑中。结合在两种转基因AD模型中amyloid斑块的减少，iAβ5p在存活神经元细胞中的显著增加以及在大脑炎症中的减少也有报道。
Ac-[Pro18, Asp21] β-amyloid (17-21), amide, iAb5p Pro18 Asp21 is a sequence with both ends blocked. Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide, also known as iAβ5p, Beta-sheet Breaker Peptide βiA 5p, is a pentapeptide with the sequence Ac-LPFFD-NH2. It is a peptide analog modified chemically to enhance its resistance to proteolysis. iAβ5p is a β-sheet breaker peptide and exhibits stronger ability to cross the blood-brain barrier (BBB) compared to most known proteins and peptides selectively taken up by the brain, suggesting its specific transport into the brain. Combined with the reduction of amyloid plaques in two transgenic AD models, significant increases in iAβ5p within surviving neuronal cells and decreased brain inflammation have also been reported.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-LPFFD-NH2 |
Sequence(3-letter code) | Ac-Leu-Pro-Phe-Phe-Asp-NH2 |
Peptide Structure | ![107P115 Ac-[Pro18, Asp21] β- Amyloid (17 - 21), amide, iAb5p Pro18 Asp21 339990-02-2.png](/SupplyImg2/2026-04-15/6391188417537590477276675.jpg "107P115 Ac-[Pro18, Asp21] β- Amyloid (17 - 21), amide, iAb5p Pro18 Asp21 339990-02-2.png")
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Molecular Formula | C35H46N6O8 |
Molecular Weight | 678.79 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： β-折叠破坏多肽;Ac-[Pro18, Asp21] β-;339990-02-2;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。