I. Basic Information (CAS: 294-90-6)
Chemical Name: Cyclen
Molecular Formula: C₈H₂₀N₄, Molecular Weight: 172.27
Appearance: White/grayish-white crystalline powder
II. Uses and Characteristics
Core Uses
Pharmaceutical Intermediate (Most Core): Key precursor for synthesizing MRI contrast agents (such as gadobenate dimeglumine); used in radiopharmaceuticals, myocardial protection, and stone removal, etc.
Strong coordination ability, forms thermodynamically and kinetically stable metal complexes, reducing the toxicity of free metals
Good water solubility and easy derivatization, suitable for pharmaceutical and functional material development
III. Parameters
Boiling Point: 283.8±8.0 °C (760 mmHg)
Density: ~0.9 g/cm³
pKa: Polyprotonated, pKa₁≈10.7, pKa₂≈9.6, pKa₃≈2.7, pKa₄≈1.8
Storage: 2–8 °C, dry, sealed, protected from light
IV. Quality Standards
Purity: ≥99.0%
Moisture: ≤0.5%
Impurities: None
Heavy Metals (Pb, As, Cd, Hg): ≤10 ppm
Residual Solvents: Complies with ICH Q3C
Microbial Limits: Complies with requirements for pharmaceutical excipients
Appearance: White powder
Melting Point: 110–112 °C
Purity (HPLC): ≥99.0%
Moisture: ≤0.3%
Toluene: ≤890 ppm.
关键字： 轮环藤宁;Cyclen;