Biotinylated Monoclonal Anti-PBD Antibody, Rabbit IgG (M1D08)
特异性(Specificity)
Specifically recognizes PBD.
抗体来源(Source)
Biotinylated Monoclonal Anti-PBD Antibody, Rabbit IgG (M1D08) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.
克隆号(Clone)
M1D08
亚型(Isotype)
Rabbit IgG | Rabbit Kappa
偶联(Conjugate)
Biotin
免疫原(Immunogen)
PBD-BSA
应用(Application)
Application | Recommended Usage |
ELISA | 0.2-125 ng/mL |
纯化(Purification)
Protein A purified / Protein G purified
制剂(Formulation)
Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.
Please contact us for customized product forms or formulations.
重构方法(Reconstitution)
Please refer to the Certificate of Analysis (CoA) for specific instructions.
For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored in a lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景介绍
Pyrrolobenzodiazepine(PBD)二聚体是用于抗体-药物偶联物(ADC)的新一代细胞毒性有效载荷。PBD二聚体与DNA小沟结合,形成有效的细胞毒性DNA链间交联,从而阻断细胞分裂并杀死癌细胞。这种作用机制利用了与微管蛋白抑制剂完全不同的细胞靶点,也产生了与其他靶向DNA的有效载荷不同的DNA损伤模式。抗PBD抗体是一种兔单克隆抗体,能特异性识别PBD,其灵敏度高于小鼠抗体。该抗PBD抗体是药代动力学(PK)检测中用于测定偶联抗体的一种有用试剂。
关键字: PBD Antibody;PBD;Anti-PBD;百普赛斯;ACRO;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。