货号:GS40723
Timigutuzumab is a humanized IgG1 kappa monoclonal antibody targeting ErbB2 (HER2/CD340), a receptor tyrosine kinase overexpressed in certain cancers. It binds to HER2 to block ligand-independent dimerization and downstream signaling pathways (e.g., PI3K/AKT, MAPK), inhibiting tumor cell proliferation and survival. It is being developed for the treatment of HER2-positive solid tumors, such as breast and gastric cancers.
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