Shiga toxin II subunit B, E. coli, 重组蛋白 (His)|TMPY-02447|TargetMol

价格	￥1890
包装	20μg

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中文名称:Shiga toxin II subunit B, E. coli, 重组蛋白 (His)	英文名称:Shiga toxin II subunit B Protein, E. coli, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Store at low temperature Store at -80°C	产品类别: 抑制剂
种属: E. coli	表达系统: E. coli
蛋白长度: A DNA sequence encoding the E.Coli STX2B (Q93EY4) (Met 1-Asp 89) was expressed, with a polyhistide tag at the N-terminus. Predicted N terminal: Met	标签: N-His
货号: T011\|TMPY-02447

名称	Shiga toxin II subunit B Protein, E. coli, Recombinant (His)
描述	E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregative Shiga-toxin–producing E. coli O104:H4, producing extended-spectrum beta-lactamase. The toxin has two subunits—A and B. E. Coli STX2B is the B subunit. It is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide. Following this, the A subunit is internalised and cleaved into two parts. Stx2 has been found to be approximately 400 times more toxic (as quantified by LD50 in mice) than Stx-1. The Stx1 and Stx2 B subunits form a pentameric structure that binds to globotriaosylceramide receptors on eukaryotic cells and promotes endocytosis.
存储条件	Store at low temperature Store at -80°C

关键字： Shiga toxin II subunit B Protein, E. coli, Recombinant (His);TargetMol

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