ALC 0366 is an ionizable cationic lipid (pKa = 6.25) developed by BioNTech, derived from ALC-0315. ALC 0366 has been used as a key component of lipid nanoparticles (LNPs) for the delivery of BNT142, an RNA encapsulated in lipid nanoparticles (RNA-LNP) that encodes a bispecific T-cell engaging antibody.
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