Product Name：Cenupatide
CAS No.：1006388-38-0
Synonyms：抑制剂Ac-Arg-Aib-Arg-α(Me)Phe-NH2
Catalog No.：218P027
Brand：Typeptide Biotech（肽研生物）
Description：Cenupatide是一种尿激酶纤溶酶原激活物受体 (uPAR) 抑制剂候选药物，是一条由4个氨基酸组成的直链小分子多肽，序列中含有两个非天然氨基酸。Cenupatide抑制uPAR与甲酰肽受体(FPR)的结合可以改善链脲佐菌素(STZ)诱导的糖尿病大鼠模型中的肾脏损伤。实验发现Cenupatide可恢复STZ诱导的uPA水平和活性上调，而足细胞上的uPAR和(s)uPAR不受影响。同事在肾小球中，Cenupatide能抑制FPR2表达，表明该药物可能作用于下游uPAR，并恢复了αvβ3整合素/Rac-1 途径的活性增加，表明uPAR在调节足细胞功能中的主要作用。
Cenupatide is a candidate drug that inhibits the urokinase plasminogen activator receptor (uPAR), a small linear polypeptide composed of four amino acids, with two non-natural amino acids in its sequence. By inhibiting the binding of uPAR to the formyl peptide receptor (FPR), Cenupatide can improve renal damage in a streptozotocin (STZ)-induced diabetic rat model. Experimental findings reveal that Cenupatide restores the upregulation of uPA levels and activity induced by STZ, while uPAR and (s)uPAR on podocytes remain unaffected. Additionally, in the glomeruli, Cenupatide suppresses FPR2 expression, suggesting the drug may act downstream of uPAR and restore the increased activity of the αvβ3 integrin/Rac-1 pathway, indicating uPAR's pivotal role in regulating podocyte function.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-R-Aib-R-N-Me-Phe-NH2 |
Sequence(3-letter code) | Ac-Arg-Aib-Arg-N-Me-Phe-NH2 |
Peptide Structure | 
|
Molecular Formula | C28H47N11O5 |
Molecular Weight | 617.75 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： Cenupatide;抑制剂Ac-Arg-Aib-Arg-α(;1006388-38-0;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。