product name: Cornuside
cas no.:131189-57-6
chemical name;Methyl (2R,3S,4R)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate
molecular formula: C24H30O14
molecular weight: 542.49
solubility: soluble in Pyridine, Methanol
appearance: powder
purity by hplc: >98%
biological activity:Cornuside has immunomodulatory activity; Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells; Cornuside can treat myocardial I/R and protect the liver from CCl?-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses; Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells; Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
关键字： 山茱萸新苷;山茱萸裂甙;Cornuside;Cornuside I
上海水正生物医药科技有限公司（Arethusa-水正生物）是一家专业从事高纯度天然药物单体的研发及销售的科技型企业。主营业务包括中药对照品、植物标准品、天然药物活性单体、药物杂质分离纯化、工艺开发研究及技术外包服务。
水正生物致力于构建全球最有影响力的“大规模、高质量天然产物库”，为全球创新药物研发机构提供丰富的物质基础，为全产业发展搭建基础性支撑平台。该库现已拥有3,000余种结构类型多样的天然化合物，几乎涵盖绝大部分已知的天然产物结构类型，其中超过60%的产品无法从商业渠道获得或现货供应商极少，它们源于650多种药用植物或真菌（包括部分中药），并且品种仍在持续丰富。