Product Name：GO-203
CAS No.：1222186-26-6
Synonyms：D型穿膜肽GO-203
Catalog No.：218P126
Brand：Typeptide Biotech（肽研生物）
Description：GO-203是一种D型氨基酸的多肽片段，序列中含有16个氨基酸，具有细胞通透性，能抑制MUC1-C二聚化，因而抑制其致瘤作用。GO-203对过表达MUC1的SKCO-1和Colo-205结肠癌细胞处理以GO-203能下调TIGAR蛋白。GO-203在大肠癌细胞中能调节AKT-S6K1-elF4A信号，抑制p-AKT。GO-203的处理还可导致ROS的增加、线粒体跨膜电位损失。体内研究：在小鼠移植瘤模型中，GO-203可有效地抑制MUC1阳性的大肠癌细胞的生长和生存。它在乳腺移植瘤、前列腺移植瘤以及肺癌和某些恶性血液病中有抗瘤活性。
GO-203 is a peptide fragment of D-type amino acids, containing 16 amino acids in its sequence. It exhibits cell permeability and inhibits MUC1-C dimerization, thereby suppressing its tumorigenic effects. Treatment with GO-203 downregulates the TIGAR protein in SKCO-1 and Colo-205 colon cancer cells overexpressing MUC1. In colorectal cancer cells, GO-203 modulates the AKT-S6K1-elF4A signaling pathway and inhibits p-AKT. Additionally, GO-203 treatment leads to increased ROS levels and mitochondrial transmembrane potential loss. In vivo studies: In mouse xenograft models, GO-203 effectively inhibits the growth and survival of MUC1-positive colorectal cancer cells. It demonstrates antitumor activity in breast and prostate xenografts, as well as in lung cancer and certain hematologic malignancies.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | RRRRRRRRRCQCRRKN（全D型） |
Sequence(3-letter code) | H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Cys-D-Gln-D-Cys-D-Arg-D-Arg-D-Lys-D-Asn-OH |
Peptide Structure | 
|
Molecular Formula | C87H170N52O19S2 |
Molecular Weight | 2312.78 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： GO-203;D型穿膜肽GO-203;1222186-26-6;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。