High-purity phosphoramidite reagent used in solid-phase oligonucleotide synthesis for DNA/RNA and siRNA/ASO drug development.
用于寡核苷酸（DNA/RNA/siRNA/ASO）合成的关键亚磷酰胺试剂，是核酸药物产业链核心基础原料之一。
Bis(2-cyanoethyl)-N,N-diisopropyl phosphoramidite
CAS: 102690-88-0
Molecular Formula: C12H22N3O2P
Molecular Weight: 271.30
Appearance: Light yellow oily liquid
Purity: ≥98%
Grade: Oligonucleotide synthesis grade
Storage: -20°C, inert gas protection
Applications 应用领域
Technical Advantages 技术优势
High purity suitable for oligonucleotide coupling efficiency
Ultra-low moisture content (<0.05% preferred)
Low phosphine oxide impurity
Strict anhydrous and oxygen-free manufacturing control
Nitrogen-filled packaging available
Stable batch-to-batch consistency
Supply Capability 供应能力
Available from gram to kilogram scale
Custom packaging under nitrogen protection
Fast delivery for regular specifications
OEM / bulk supply available for CDMO customers
Mechanism of Use 使用原理
This phosphoramidite reacts under tetrazole activation with hydroxyl groups during solid-phase oligonucleotide synthesis, forming a phosphite triester intermediate, which is subsequently oxidized to stable phosphate linkage.
The cyanoethyl protecting groups are removed under ammonolysis conditions.
We specialize in supplying high-purity oligonucleotide building blocks for RNA drug development companies worldwide.
关键字： phosphoramidite re;oligonucleotide sy;DNA RNA building b;siRNA raw material;ASO raw material;
江苏星火渔影生物科技有限公司是一家化学品合同定制研发及生产企业，主营业务基于药物分子砌块的药物开发和生产服务 (CDMO)。