重组人R-Spondin 1/RSPO1蛋白, HPLC-verified

Recombinant Human R‑Spondin 1 / RSPO1 Protein

Cat No: 11083‑HNAS｜Official product page:        https://cn.sinobiological.com/recombinant-proteins/human-rspo1-11083-hnas

Specifications

Alternate Names

Background

RSPO1 gene is a member of the R‑spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein‑rich, furin‑like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy‑induced adverse effects. This protein is an activator of the beta‑catenin signaling cascade, leading to TCF‑dependent gene activation. RSPO1 acts both in the canonical Wnt/beta‑catenin‑dependent pathway and in non‑canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

北京义翘神州科技股份有限公司作为国家高新技术企业，主要从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务，同时也为制药公司或者生物技术公司提供单克隆抗体候选药物的临床前规模生产服务。义翘神州拥有多项先进的核心技术以及从研发生产到放大生产的技术平台，为重组蛋白或者抗体试剂的高通量、高效率研发生产提供保障，旨在为全球制药企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。 北京义翘神州是入选科技部"现代服务创新发展示范企业"的唯一的一家生物技术企业，是北京市民营企业科技创新百强，获批北京市单克隆抗体技术重点实验室，多次承担国家科技部重大新药创制专项、863科技攻关项目和北京市科委项目。