PROTAC K-Ras Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to promote targeted degradation of K-Ras (KRAS), a small GTPase that plays a central role in RAS/MAPK signaling and is frequently implicated in cancer development and progression. The compound contains a KRAS-targeting moiety and an E3 ubiquitin ligase-recruiting component connected through a polyethylene glycol (PEG)-containing linker, enabling formation of a ternary complex and promoting ubiquitination and subsequent degradation of KRAS through the ubiquitin–proteasome system. The chemical name of PROTAC K-Ras Degrader-1 is 2-((2S)-1-acryloyl-4-(2-(((2S,4R)-4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile.
PROTAC K-Ras Degrader-1 has a CAS No. of 2378258-52-5, a molecular formula of C₅₃H₆₂N₁₀O₁₀, and a molecular weight of 999.12 g/mol. It is intended for research applications involving KRAS degradation, targeted protein degradation, PROTAC technology, RAS/MAPK signaling, cancer biology, and KRAS-driven cancer research. The compound can be used as a research tool for investigating KRAS-dependent cellular signaling and the biological effects of targeted KRAS depletion. For research use only.
关键字： PROTAC;RAS signaling;MAPK pathway;ERK signaling;KRAS-driven cancer;
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