PROTAC SGK3 Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to promote targeted degradation of serum/glucocorticoid-regulated kinase 3 (SGK3), a serine/threonine protein kinase involved in intracellular signaling, cell growth, survival, and metabolic regulation. The compound contains an SGK3-targeting ligand connected to an E3 ubiquitin ligase-recruiting moiety through a linker, facilitating formation of a ternary complex and promoting ubiquitination and subsequent degradation of SGK3 through the ubiquitin–proteasome system. The chemical name of PROTAC SGK3 Degrader-1 is (2S,4R)-1-((S)-2-(tert-butyl)-18-((R)-2-(((6-(4-((2-fluoro-5-methylphenyl)sulfonamido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)methyl)morpholino)-4-oxo-6,9,12-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide.
PROTAC SGK3 Degrader-1 has a CAS No. of 2381320-35-8, a molecular formula of C₅₇H₇₃FN₁₀O₁₁S₂, and a molecular weight of 1157.38 g/mol. It is intended for research applications involving SGK3 degradation, targeted protein degradation, PROTAC technology, kinase signaling, cellular signaling, cancer biology, and tumor research. The compound can be used as a research tool for investigating SGK3-dependent pathways and the biological effects associated with targeted depletion of SGK3. For research use only.
关键字： PROTAC;SGK3 degrader;kinase degrader;PI3K/AKT signaling;cancer research;
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