瑞德西韦

EC50: 30 nM (murine hepatitis virus, delayed brain tumor cell), 74 nM (SARS-CoV, HAE cell), 74 nM (MERS-CoV, HAE cell)[1]

DMSO : ≥ 125 mg/mL (207.44 mM)

* "≥" means soluble, but saturation unknown.

1.

请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

2.

请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

3.

请依序添加每种溶剂： 10% DMSO    90% corn oil

Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.

[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.