[Drug name]
Generic name: Combined Clostridium Butyricum and Bifidobacterium Powders, Live
Brand name: Clobico
[Ingredients]
Active ingredient: Clostridium butyricum, Bifidobacterium infantis
Inactive ingredient: Corn starch, Anhydrous glucose
[Character]
This product shall be white or grayish white powder.
[Indications]
Indicated for intestinal flora imbalance and related acute and chronic diarrhea and dyspepsia.
[Specification]
500mg / sachet (within the shelf life, each sachet contains clostridium butyricum with the viable count of not less than 1.0Î107 CFU/g and bifidobacterium infantis with the viable count of not less than 1.0Î106 CFU/g)
[Usage and dosage]
Oral administration, 3 sachets a time, twice a day. For acute diarrhea, continuously use for 3~7 days; for chronic diarrhea, continuously use for 14~21 days.
[Side effects]
The Phase I ~ III of Clinical trial have showed that a few patients slightly developed skin rash and stomach upset.
[Contraindications]
Not to be taken by those who are allergic to probiotics.
[Announcements]
Not to be taken with hot water.
[Medication for pregnant women and lactation female]
It can be taken by the pregnant women and lactation female.
[Medication for children]
Oral administration, 1 sachet a time, twice a day. It can be taken with cold boiled water, juice and milk.
[Drug interaction]
Not to be taken with antibiotics at the same time.
[Drug overdose]
This product is probiotics. No overdose is reported.
[Pharmacology& Toxicology]
The pharmacodynamics test in mice showed that this product can stop diarrhea caused by ampicillin. Clostridium butyricum can inhibit the growth of intestinal pathogenic bacteria such as el tor vibrio cholerae 01 group, vibrio cholerae 0139, escherichia coli 0157, etc. This product can also inhibit the growth of shigella dysentery and salmonella porcine cholera.
[Pharmacokinetics]
Clostridium butyricum can be colonized temporarily in the intestinal tract and kept for about ten days before being eliminated from the body. Bifidobacterium infantis is a resident beneficial bacterium, which can be colonized and grown in the intestinal tract after oral administration.
[Storage]
Store at 2~8 ºC and protect from light.
[Package]
Packing material: medicinal composite membrane
Packing specification: 500mg / sachet, 10 sachets / box
[Shelf life]
24 months
[Manufacturing enterprise]
Manufacturer: Shandong Kexing Bioproducts Co., Ltd.
Manufacturing site: No. 2666 Chuangye Road, Mingshui Development Zone, Zhangqiu, Shandong, China
URL: www.gzpharm.com.cn/
关键字： Probiotics Combined Clostridium Butyricum and Bifidobacterium Powders, Live
科兴制药是一家集研发、生产、销售于一体的生物制药高新技术企业。作为中国基因工程药物产业化的开创者，公司秉承精益制药、精益用药、守护健康的理念，致力于推动高品质生物药的发展及其临床价值的持续提升，为患者健康创造更多可能。
拥有三十余年成熟的生产管理经验、雄厚的技术实力和完善的质量管理体系，在深圳和山东设立了三大生产基地，目前，科兴制药成功构建了原核表达技术平台、真核表达技术平台、长效重组蛋白技术平台、微生态技术平台等多个国内外领先的技术平台。