Chemical Safety Data Sheet MSDS / SDS

N-Phenyl-N-(4-piperidinyl)propanamide admixture with HCl salt

Revision Date:2026-03-20Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: N-Phenyl-N-(4-piperidinyl)propanamide admixture with HCl salt
CBnumber: CB4853167
CAS: 1609-66-1
EINECS Number: 216-543-3
Synonyms: NORFENTANYL

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordWarning

Precautionary statements

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P302+P352 IF ON SKIN: wash with plenty of soap and water.

Hazard statements

H319 Causes serious eye irritation

H315 Causes skin irritation

H302 Harmful if swallowed

SECTION 3: Composition/information on ingredients

Substance

Product name: N-Phenyl-N-(4-piperidinyl)propanamide admixture with HCl salt
Synonyms: NORFENTANYL
CAS: 1609-66-1
EC number: 216-543-3
MF: C14H20N2O
MW: 232.32

SECTION 4: First aid measures

Description of first aid measures

General information

Immediately remove any clothing soiled by the product.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.

After inhalation

Supply fresh air or oxygen; call for doctor.
In case of unconsciousness place patient stably in side position for transportation.

After skin contact

Immediately wash with water and soap and rinse thoroughly.

After eye contact

Rinse opened eye for several minutes under running water. Then consult a doctor.

After swallowing

Do not induce vomiting; immediately call for medical help.

Information for doctor

Most important symptoms and effects, both acute and delayed

No further relevant information available.

Indication of any immediate medical attention and special treatment needed

No further relevant information available.

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing agents

CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.

Special hazards arising from the substance or mixture

67-56-1During heating or in case of fire poisonous gases are produced.

Advice for firefighters

Protective equipment

Mouth respiratory protective device.

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Mount respiratory protective device.
Wear protective equipment. Keep unprotected persons away.

Environmental precautions

Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.

Methods and material for containment and cleaning up

Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.

Reference to other sections

See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

Protective Action Criteria for Chemicals

PAC-1

67-56-1 Methanol 530 ppm

PAC-2

67-56-1 Methanol 2,100 ppm

PAC-3

67-56-1 Methanol 7200* ppm

SECTION 7: Handling and storage

Handling

Precautions for safe handling

Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
Prevent formation of aerosols.

Information about protection against explosions and fires

Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
Keep respiratory protective device available.

Conditions for safe storage, including any incompatibilities

Storage

Store in accordance with information listed on the product insert.

Requirements to be met by storerooms and receptacles

Store in a cool location.

Information about storage in one common storage facility

Not required.

Further information about storage conditions

Keep receptacle tightly sealed.
Store in cool, dry conditions in well sealed receptacles.

Specific end use(s)

No further relevant information available.

SECTION 8: Exposure controls/personal protection

Additional information about design of technical systems

No further data; see section 7.

Control parameters

Components with limit values that require monitoring at the workplace:
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.

67-56-1 Methanol
PEL	Long-term value: 260 mg/m³, 200 ppm
REL	Short-term value: 325 mg/m³, 250 ppm Long-term value: 260 mg/m³, 200 ppm Skin
TLV	Short-term value: 250 ppm Long-term value: 200 ppm Skin; BEI

67-56-1 Methanol
Ingredients with biological limit values:
BEI	15 mg/L Medium: urine Time: end of shift Parameter: Methanol (background, nonspecific)

Additional information

The lists that were valid during the creation were used as basis.

Exposure controls

Personal protective equipment

General protective and hygienic measures

Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.

Breathing equipment

In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.

Protection of hands

Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation

Material of gloves

The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application.

Penetration time of glove material

The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.

Eye protection

Tightly sealed goggles

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Other informationNo information available
Solids content0.1 %
VOC content99.90 % 999.0 g/l / 8.34 lb/gal
Organic solvents99.9 %
KinematicNot determined.
DynamicNot determined.
Partition coefficient (n-octanol/water)Not determined.
WaterFully miscible.
Solubility in / Miscibility withDMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
Evaporation RateNot determined.
Vapor DensityNot determined.
Relative Density1.075±0.06 g/cm3(Predicted)
Density at 20 °C (68 °F)0.79 g/cm³ (6.59255 lbs/gal)
Vapor Pressure at 20 °C (68 °F)128 hPa (96 mm Hg)
Explosion limitsLower: 5.5 Vol %
Upper: 44 Vol %
Danger of explosionProduct is not explosive. However, formation of explosive air/ vapor mixtures are possible.
Ignition temperatureProduct is not selfigniting.
Decomposition temperatureNot determined.
Auto igniting455 °C (851 °F)
Flammability (solid,gas)Highly flammable.
Flash point11 °C (51.8 °F)
Boiling point/Boiling range64.7 °C (148.5 °F)
Melting point/Melting range-98 °C (-144.4 °F)
pHNot determined.
FormulationA 1 mg/ml solution in methanol
Odor ThresholdNot determined.
Molecular Weight232.3 g/mol
Structural FormulaC14H20N2O
OdorAlcohol-like
ColorAccording to product specification
Physical StateLiquid
Vapour pressure0.001-0.002Pa at 20-25℃
Water solubilityInsoluble in water.

SECTION 10: Stability and reactivity

Reactivity

No further relevant information available.

Chemical stability

Thermal decomposition / conditions to be avoided

No decomposition if used according to specifications.

Possibility of hazardous reactions

No dangerous reactions known.

Conditions to avoid

No further relevant information available.

Incompatible materials

oxidizing agents

Hazardous decomposition products

carbon monoxide, carbon dioxide

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD/LC50 values that are relevant for classification:

Substance / Estimate	Route	Endpoint	Value
ATE (Acute Toxicity Estimate)	Oral	LD50	100 mg/kg
ATE (Acute Toxicity Estimate)	Dermal	LD50	300 mg/kg
ATE (Acute Toxicity Estimate)	Inhalative	LC50/4 h	3 mg/l
67-56-1 Methanol	Oral	LDLO	143 mg/kg (hmn)
67-56-1 Methanol	Oral	TDLO	5 ml/kg (rat)
67-56-1 Methanol	Oral	LD50	5,600 mg/kg (rat)
67-56-1 Methanol	Dermal	LD50	15,800 mg/kg (rabbit)
67-56-1 Methanol	Inhalative	LC50/4 h	64,000 mg/m³ (rat)
67-56-1 Methanol	Inhalative	LC50	61,100 mg/m³/134 m (mouse) Irritation of skin Irritation 20 mg/24h (rabbit) Irritation (rabbit) Irritation 5.63 mg/kg/exempt preparation (rabbit) Irritation of eyes Irritation 40 mg (rabbit)
67-56-1 Methanol	Intraperitoneal	TDLO	5 mg/kg (rat)
67-56-1 Methanol	Intraperitoneal	LD50	10,765 mg/kg (mouse)
67-56-1 Methanol	Subcutaneous	LD50	143 mg/kg/human (mouse) Data 20 mg/24h (rabbit)

Primary irritant effect

on the skin

No irritant effect.

on the eye

No irritating effect.

Sensitization

Sensitization possible through skin contact.

Additional toxicological information

The product shows the following dangers according to internally approved calculation methods for preparations
Toxic
Irritant

Carcinogenic categories

IARC (International Agency for Research on Cancer)

None of the ingredients is listed.

NTP (National Toxicology Program)

None of the ingredients is listed.

OSHA-Ca (Occupational Safety & Health Administration)

None of the ingredients is listed.

SECTION 12: Ecological information

Toxicity

Aquatic toxicity

No further relevant information available.

Persistence and degradability

No further relevant information available.

Behavior in environmental systems

Bioaccumulative potential

No further relevant information available.

Mobility in soil

No further relevant information available.

Additional ecological information

General notes

Water hazard class 2 (Self-assessment) hazardous for water
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.

Results of PBT and vPvB assessment

PBT

Not applicable.

vPvB

Not applicable.

PBT:

Not applicable.

vPvB:

Not applicable.

Other adverse effects

No further relevant information available.

SECTION 13: Disposal considerations

Waste treatment methods

Recommendation

Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Uncleaned packagings

Recommendation

Disposal must be made according to official regulations.

Recommended cleansing agent

Water, if necessary with cleansing agents.

SECTION 14: Transport information

UN-Number

DOT, IMDG, IATA UN1230

UN proper shipping name

DOT, IATA Methanol solution
IMDG METHANOL solution

Transport hazard class(es)

DOT

Class: 3 Flammable liquids
Label: 3, 6.1

IMDG

Class: 3 Flammable liquids
Label: 3/6.1

IATA

Class: 3 Flammable liquids
Label: 3 (6.1)

Packing group

DOT, IMDG, IATA II

Environmental hazards

Not applicable.

Special precautions for user

Warning: Flammable liquids

Hazard identification number (Kemler code)

336

EMS Number

F-E,S-D

Stowage Category

Stowage Code

SW2 Clear of living quarters.

Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code

Not applicable.

Transport/Additional information

DOT:

Quantity limitations

On passenger aircraft/rail: 1 L
On cargo aircraft only: 60 L

IMDG:

Limited quantities (LQ)

Excepted quantities (EQ)

Code: E2
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml

IATA:

Remarks

When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.

UN "Model Regulation"

UN 1230 METHANOL SOLUTION, 3 (6.1), II

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

No further relevant information available.

Sara

Section 355 (extremely hazardous substances):	None of the ingredients is listed.
Section 313 (Specific toxic chemical listings):	67-56-1 Methanol
TSCA (Toxic Substances Control Act):	67-56-1 Methanol ACTIVE
Hazardous Air Pollutants 67-56-1 Methanol

Proposition 65

Chemicals known to cause cancer:	None of the ingredients is listed.
Chemicals known to cause reproductive toxicity for females:	None of the ingredients is listed.
Chemicals known to cause reproductive toxicity for males:	None of the ingredients is listed.
Chemicals known to cause developmental toxicity:	67-56-1 Methanol

Carcinogenic categories

EPA (Environmental Protection Agency):

None of the ingredients is listed.

TLV (Threshold Limit Value)

None of the ingredients is listed.

NIOSH-Ca (National Institute for Occupational Safety and Health)

None of the ingredients is listed.

Chemical safety assessment

A Chemical Safety Assessment has not been carried out.

SECTION 16: Other information

Abbreviations and acronyms

IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
BEI: Biological Exposure Limit
Flammable Liquids 2: Flammable liquids – Category 2
Acute Toxicity - Oral 3: Acute toxicity – Category 3
Sensitization - Skin 1: Skin sensitisation – Category 1
Specific Target Organ Toxicity - Single Exposure 1: Specific target organ toxicity (single exposure) – Category 1

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.