Chemical Safety Data Sheet MSDS / SDS
2-Nitrotoluene
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 2-Nitrotoluene
- CBnumber: CB1854572
- CAS: 88-72-2
- EINECS Number: 201-853-3
- Synonyms: Ortho Nitrotoluene;Benzene,1-methyl-2-nitro-
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P308+P313 IF exposed or concerned: Get medical advice/attention.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P273 Avoid release to the environment.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P202 Do not handle until all safety precautions have been read and understood.
Hazard statements
H411 Toxic to aquatic life with long lasting effects
H350 May cause cancer
H340 May cause genetic defects
H302 Harmful if swallowed
Substance
- Product name: 2-Nitrotoluene
- Synonyms: Ortho Nitrotoluene;Benzene,1-methyl-2-nitro-
- CAS: 88-72-2
- EC number: 201-853-3
- MF: C7H7NO2
- MW: 137.14
General advice
Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products
Carbon oxides Nitrogen oxides (NOx)
Specific extinguishing methods
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
NFPA 704
3
1
1
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material . Dispose of properly. Clean up affected area.
Handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Storage
Further information on storage conditionsTightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class
6.1A, Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
Recommended storage temperature
Recommended storage temperature see product label.
Ingredients with workplace control parameters
Biological occupational exposure limits
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter A (acc. to DIN 3181) for vapours of organic
type
compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
protective clothing
Hand protection
Material
butyl-rubber
Break through time
480 min
Glove thickness
0.7 mm
Protective index
Full contact
Manufacturer
Butoject® (KCL 898)
Material
Nitrile rubber
Break through time
30 min
Glove thickness
0.4 mm
Protective index
Splash contact
Manufacturer
Camatril® (KCL 730 / Aldrich Z677442, Size M)
Remarks
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D- 36124 Eichenzell, Internet: www.kcl.de).
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Solubility0.65g/l (experimental)
- Physical stateLiquid
- Henry's Law Constant1.25 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
- Dielectric constant27.399999999999999
- Particle characteristics Particle sizeNo data available
- Molecular weight137.14 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamic2.37 mPa.s
- Autoignition temperature420 °C
Decomposition temperature Viscosity: No data available - Partition coefficient: n-octanol/waterlog Pow: 2.30
Method Bioaccumulation is not expected. (Lit.): (experimental) - Water solubility0.65 g/l (experimental) (20 °C)
- Density1.163 g/cm3 (25 °C)
Method: lit. - Relative density1.163 g/mL at 25 °C(lit.)
- Relative vapor density4.73
- Vapor pressure0.1 hPa (20 °C)
- Lower explosion limit / Lower flammability limitLower explosion limit
- Upper explosion limit / Upper flammability limitUpper explosion limit
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash point95 °C
Method: closed cup, closed cup - Boiling point/boiling range225 °C
Method: lit. - Melting point/ range-4 - -3 °C
Method: lit. - pH6 - 8
- Odor ThresholdNo data available
- Odoraromatic
- Coloryellow
- Appearanceliquid
Reactivity
Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Exothermic reaction with: Strong oxidizing agents Risk of explosion with: Sulphur trioxide sulfuric acid Reducing agents increased reactivity with: strong alkalis Amines
Conditions to avoid
Strong heating.
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - 891 mg/kg
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary oe- dema and pneumonitis.
Remarks: (RTECS)
Oral: absorption
Symptoms: Dizziness, Nausea, Vomiting
Inhalation: absorption
Dermal: absorption
Skin corrosion/irritation
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary oe- dema and pneumonitis.
Remarks: (RTECS)
Oral: absorption
Symptoms: Dizziness, Nausea, Vomiting
Inhalation: absorption
Dermal: absorption
Skin - Rabbit
Result: No skin irritation - 24 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: No skin irritation - 24 h (OECD Test Guideline 404)
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
May cause genetic defects.
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 479
Result: positive
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Mutagenicity (mammal cell test): micronucleus.
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 487
Result: positive
Test Type: Unscheduled DNA synthesis test (UDS) in testicular cells
Species: Rat
Cell type: Liver cells
Application Route: Oral
Method: OECD Test Guideline 486
Result: positive
Carcinogenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 479
Result: positive
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Mutagenicity (mammal cell test): micronucleus.
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 487
Result: positive
Test Type: Unscheduled DNA synthesis test (UDS) in testicular cells
Species: Rat
Cell type: Liver cells
Application Route: Oral
Method: OECD Test Guideline 486
Result: positive
Carcinogenicity - (ECHA)
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Presumed to have carcinogenic potential for humans
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: XT3150000
Absorption into the body leads to the formation of methemoglobin which in suffi- cient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer.,
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
Methaemoglobinaemia with headache, cardiac arrhythmia, drop in blood pressure, dyspnoea, and spasms, key symptom: cyanosis (blue colouration of the blood).
Effect potentiated by: ethanol flush of face, neck and arms muscular weakness cardiovascular disorders confusion
Absorption may result in damage of the following:
Liver
Kidney spleen
The following applies to aromatic nitro compounds in general: systemic effect: methaemoglobinaemia with headache, cardiac dysrhythmias, drop in blood pres- sure, dyspnoea, and spasms; principal sign: cyanosis (blue discolouration of the blood).
This substance should be handled with particular care.
Absorption into the body leads to the formation of methemoglobin which in suffi- cient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer.,
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
Methaemoglobinaemia with headache, cardiac arrhythmia, drop in blood pressure, dyspnoea, and spasms, key symptom: cyanosis (blue colouration of the blood).
Effect potentiated by: ethanol flush of face, neck and arms muscular weakness cardiovascular disorders confusion
Absorption may result in damage of the following:
Liver
Kidney spleen
The following applies to aromatic nitro compounds in general: systemic effect: methaemoglobinaemia with headache, cardiac dysrhythmias, drop in blood pres- sure, dyspnoea, and spasms; principal sign: cyanosis (blue discolouration of the blood).
This substance should be handled with particular care.
Ecotoxicity
Components:
2-nitrotoluene:
Toxicity to fishLC50 (Poecilia reticulata (guppy)): 30.1 mg/l Exposure time: 96 h Remarks: (ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 5.4 mg/l Exposure time: 48 h Remarks: (ECOTOX Database)
Toxicity to algae/aquatic plants
ErC50 (Chlorella pyrenoidosa (algae)): 22 mg/l Exposure time: 72 h Test Type: Growth inhibition Method: OECD Test Guideline 201 GLP: yes NOEC (Chlorella pyrenoidosa (algae)): 4.4 mg/l Exposure time: 72 h Test Type: Growth inhibition Method: OECD Test Guideline 201 GLP: yes
Toxicity to fish (Chronic toxicity)
NOEC (Oryzias latipes (Orange-red killifish)): 1.9 mg/l Exposure time: 28 d Remarks: (ECHA)
Persistence and degradability
No data available
Bioaccumulative potential
Components:
2-nitrotoluene:
Partition coefficient: noctanol/waterlog Pow: 2.30 Method: (experimental) Remarks: Bioaccumulation is not expected. (Lit.)
Mobility in soil
No data available
Other adverse effects
Components:
2-nitrotoluene:
Additional ecological informationDischarge into the environment must be avoided.
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 1664
Proper shipping name : Nitrotoluenes, liquid
Class : 6.1
Packing group : II
Labels : Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 662
Packing instruction (passenger aircraft) : 654
Proper shipping name : Nitrotoluenes, liquid
Class : 6.1
Packing group : II
Labels : Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 662
Packing instruction (passenger aircraft) : 654
IMDG-Code
UN number : UN 1664
Proper shipping name : NITROTOLUENES, LIQUID
Class : 6.1
Packing group : II
Labels : 6.1
EmS Code : F-A, S-A
Marine pollutant : yes
Proper shipping name : NITROTOLUENES, LIQUID
Class : 6.1
Packing group : II
Labels : 6.1
EmS Code : F-A, S-A
Marine pollutant : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : UN 1664
Proper shipping name : NITROTOLUENES, LIQUID
Class : 6.1
Packing group : II
Labels : 6.1
Environmentally hazardous : no
Proper shipping name : NITROTOLUENES, LIQUID
Class : 6.1
Packing group : II
Labels : 6.1
Environmentally hazardous : no
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals
Hazardous Chemicals for Priority Management
Not applicable under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not applicable
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
ACGIH BEI
ACGIH - Biological Exposure Indices (BEI)
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
GBZ 2.1-2007 / PC-TWA AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardisation; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; MERC of Dangerous Goods; n.o. - No Observed (Adverse) fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organisatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Permissible concentration - time weighted average ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.