Chemical Safety Data Sheet MSDS / SDS
3,5-Difluoroanisole
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 3,5-Difluoroanisole
- CBnumber: CB1263266
- CAS: 93343-10-3
- Synonyms: 3-difluoroanisile;3，5-difluoroanisile
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P501 Dispose of contents/container to..…
P403+P235 Store in a well-ventilated place. Keep cool.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P405 Store locked up.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H315 Causes skin irritation
H226 Flammable liquid and vapour
Substance
- Product name: 3,5-Difluoroanisole
- Synonyms: 3-difluoroanisile;3，5-difluoroanisile
- CAS: 93343-10-3
- MF: C7H6F2O
- MW: 144.12
Eye Contact
Immediate medical attention is required. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Skin Contact
Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Get medical attention.
Take off contaminated clothing and shoes immediately.
Take off contaminated clothing and shoes immediately.
Inhalation
Remove from exposure, lie down. Remove to fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Immediate medical attention is required.
Ingestion
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Drink plenty of water. Call a physician immediately. If possible drink milk afterwards.
Most important symptoms and effects
Difficulty in breathing. Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting
Self-Protection of the First Aider
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Water spray. Carbon dioxide (CO2). Dry chemical. Alcohol resistant foam. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Flammable.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA 704
2
2
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
desc_info
| Personal Precau | tions | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ensure adequate | ventilation. | ||||||||||||||||
| Environmental P | recautions | ||||||||||||||||
| See Section 12 fo | r additional | Ecological | Inf | ormati | on. | ||||||||||||
| Methods for Con | tainment a | nd Clean U | p | ||||||||||||||
| Soak up with inert | absorbent | material (e. | g. | sand, | silica | gel, | acid | binde | r, | u | niversal | binder, | sawdust). | Keep | in | suitable, | closed |
| containers for dis | posal. Swee | p up and s | ho | vel int | o suita | ble | conta | iners | fo | r | disposal | . | |||||
| Refer to protective | measures | listed in Se | cti | ons 8 | and 1 | 3. |
Handling
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous.
Storage
Flammables area. Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Specific Use(s)
Use in laboratories
Control Parameters
Exposure Controls
Engineering Measures
Ensure adequate ventilation, especially in confined areas. Ventilation systems. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionWear safety glasses with side shields (or goggles) Goggles (European standard - EN 166)
Hand Protection
Protective gloves
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Disposable gloves | See manufacturers recommendations | - | EN 374 | (minimum requirement) |
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Wear appropriate protective gloves and clothing to prevent skin exposure
Respiratory Protection
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Wear a
NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Large scale/emergency use
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Wear a
NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
In case of insufficient ventilation, wear suitable respiratory equipment
Small scale/Laboratory use
Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
When RPE is used a face piece Fit Test should be conducted
When RPE is used a face piece Fit Test should be conducted
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
No information available.
Information on basic physicochemical properties
- Molecular Weight144.12
- Molecular FormulaC7 H6 F2 O
- Oxidizing PropertiesNo information available
- Explosive PropertiesNo information available
- ViscosityNo data available
- Decomposition TemperatureNo data available
- Autoignition TemperatureNo data available
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsNo information available
- Water SolubilityNo information available
- Bulk Density1.234 g/mL at 25 °C (lit.)
- Specific Gravity / Density1.230
- Vapor Density4.9 7 (Air = 1.0)
- Vapor PressureNo information available
- Explosion LimitsNo data available
- Flammability (solid,gas)No information available
- Evaporation RateNo data available
- Flash Point43 °C / 109.4 °F Method - No information available
- Boiling Point/Range145-148°C
- Softening PointNo data available
- Melting Point/RangeNo data available
- pHNo information available
- Odor ThresholdNo data available
- OdorOdorless
- Physical StateLiquid
- AppearanceColorless
- ColourClear colorless
Stability
Stable under normal conditions.
Hazardous Reactions
No information available.
Hazardous Polymerization
No information available.
Conditions to Avoid
None known.
Materials to avoid
Oxidizing agent.
Hazardous Decomposition Products
Thermal decomposition can lead to release of irritating gases and vapors. Carbon monoxide (CO). Carbon dioxide (CO2). Gaseous hydrogen fluoride (HF).
Product Information
No acute toxicity information is available for this product
(a) acute toxicity;
(b) skin corrosion/irritation;
No data available
(c) serious eye damage/irritation;
No data available
(d) respiratory or skin sensitization;
RespiratoryNo data available
Skin
No data available
(e) germ cell mutagenicity;
No data available
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
| (h) STOT-single exposure; | No data available | |
|---|---|---|
| Results / Target organs | Respiratory system | |
| (i) STOT-repeated exposure; | No data available | |
| Target Organs | No information available. | |
| (j) aspiration hazard; | No data available |
Ecotoxicity effects
.
| Component | Freshwater Fish | Water Flea | Freshwater Algae | Microtox |
|---|---|---|---|---|
| 3,5-Difluoroanisole | EC50 = 61.5 mg/L 5 min EC50 = 73.9 mg/L 15 min EC50 = 93.1 mg/L 30 min |
Persistence and Degradability
No information available
Bioaccumulative Potential
No information available
Mobility in soil
No information available
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.
Contaminated Packaging
Empty remaining contents. Dispose of in accordance with local regulations. Do not re-use empty containers.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used.
Road and Rail Transport
UN-NoUN1993
Proper Shipping Name
Flammable liquid, n.o.s.
Hazard Class
3
IATA
UN-NoUN1993
Proper Shipping Name
FLAMMABLE LIQUID, N.O.S.*
Hazard Class
3
Packing Group
III
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3,5-Difluoroanisole | - | - | X | - | - | - | - | - | - | - | - |
National Regulations
Prepared By
Health, Safety and Environmental Department
Revision Date
14-Sep-2025
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.