Chemical Safety Data Sheet MSDS / SDS
4-ETHYLBENZOPHENONE
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 4-ETHYLBENZOPHENONE
- CBnumber: CB6212663
- CAS: 18220-90-1
- EINECS Number: 242-101-4
- Synonyms: Ketoprofen Impurity 49;(4-Ethylphenyl)(phenyl)methanone
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P273 Avoid release to the environment.
P264 Wash skin thouroughly after handling.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Hazard statements
H372 Causes damage to organs through prolonged or repeated exposure
H411 Toxic to aquatic life with long lasting effects
H315 Causes skin irritation
Substance
- Product name: 4-ETHYLBENZOPHENONE
- Synonyms: Ketoprofen Impurity 49;(4-Ethylphenyl)(phenyl)methanone
- CAS: 18220-90-1
- EC number: 242-101-4
- MF: C15H14O
- MW: 210.27
Eye Contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.
Skin Contact
Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur.
Inhalation
Remove to fresh air. Get medical attention immediately if symptoms occur.
Ingestion
Clean mouth with water and drink afterwards plenty of water. Get medical attention if symptoms occur.
Most important symptoms and effects
None reasonably foreseeable.
Self-Protection of the First Aider
No special precautions required.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Thermal decomposition can lead to release of irritating gases and vapors.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA 704
0
1
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal Precautions
Ensure adequate ventilation. Use personal protective equipment as required. Avoid dust formation.
Environmental Precautions
Should not be released into the environment. See Section 12 for additional Ecological Information.
Methods for Containment and Clean Up
Sweep up and shovel into suitable containers for disposal. Avoid dust formation.
Refer to protective measures listed in Sections 8 and 13.
Refer to protective measures listed in Sections 8 and 13.
Handling
Wear personal protective equipment/face protection. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Avoid dust formation.
Storage
Keep container tightly closed in a dry and well-ventilated place.
Specific Use(s)
Use in laboratories
Control Parameters
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS14/3 General methods for sampling and gravimetric analysis of respirable and inhalable dust MDHS70 General methods for sampling airborne gases and vapours MDHS 96 Volatile organic compounds in air -
Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Exposure Controls
Engineering Measures
None under normal use conditions. .
Personal protective equipment
Eye ProtectionWear safety glasses with side shields (or goggles) (European standard - EN 166)
Hand Protection
Protective gloves
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Nitrile rubber | See manufacturers | - | EN 374 | (minimum requirement) |
| Neoprene | recommendations | |||
| Natural rubber | ||||
| PVC |
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Long sleeved clothing
Respiratory Protection
No protective equipment is needed under normal use conditions.
Large scale/emergency use
Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Particle filter
Small scale/Laboratory use
Maintain adequate ventilation
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
No information available.
Information on basic physicochemical properties
- Autoignition TemperatureNo data available
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsNo information available
- Water SolubilityInsoluble in water
- Bulk Density1.0232 (rough estimate)
- Specific Gravity / Density1.0232 (rough estimate)
- Vapor DensityNot applicable Solid
- Vapor PressureNo data available
- Explosion LimitsNo data available
- Flammability (solid,gas)No information available
- Evaporation RateNot applicable Solid
- Flash Point> 110 °C / > 230 °F Method - No information available
- Boiling Point/Range150 °C / 302 °F
- Softening PointNo data available
- Melting Point/RangeNo data available
- pHNo information available
- Odor ThresholdNo data available
- OdorNo information available
- Physical StateSolid
- AppearanceColorless
- Molecular Weight210.28
- Molecular FormulaC15 H14 O
- Oxidizing PropertiesNo information available
- Explosive PropertiesNo information available
- ViscosityNot applicable Solid
- Decomposition TemperatureNo data available
Stability
Stable under normal conditions.
Hazardous Reactions
None under normal processing.
Hazardous Polymerization
No information available.
Conditions to Avoid
None known.
Materials to avoid
No information available.
Hazardous Decomposition Products
None under normal use conditions.
Product Information
(a) acute toxicity;
(b) skin corrosion/irritation;
No data available
(c) serious eye damage/irritation;
No data available
(d) respiratory or skin sensitization;
Respiratory
No data available
Skin
No data available
(e) germ cell mutagenicity;
No data available
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
(h) STOT-single exposure;
No data available
(i) STOT-repeated exposure;
No data available
Target Organs
No information available.
(j) aspiration hazard;
Not applicable
Solid
Solid
Symptoms / effects,both acute and delayed
No information available
desc_info
| Ecotoxicity effect | s | Contains no | s | ubst | ances | known | to | b | e hazard | ous to the | environment | or | that are not | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| degradable i | n | was | te wat | er treat | me | nt plants. | ||||||||
| Persistence and | Degradability | |||||||||||||
| Persistence | Insoluble in | wa | ter, | Persis | tence i | s u | nlikely, ba | sed on inf | ormation avail | a | ble. | |||
| Bioaccumulative | Potential | May have so | m | e po | tentia | l to bio | acc | umulate | ||||||
| Mobility in soil | Spillage unli | ke | ly to | penet | rate so | il T | he produ | ct contains | volatile organ | ic | compounds | (VOC) | ||
| which will ev | a | pora | te easi | ly from | all | surfaces | Is not likel | y mobile in th | e | environment | due its | |||
| low water so | lu | bility | Will li | kely be | m | o | bile in th | e environm | ent due to its | v | olatility | |||
| Endocrine Disrup | tor Information | This product | d | oes | not co | ntain a | ny | k | nown or | suspected | endocrine dis | ru | ptors | |
| Persistent Organ | ic Pollutant | This product | d | oes | not co | ntain a | ny | k | nown or | suspected | substance | |||
| Ozone Depletion | Potential | This product | d | oes | not co | ntain a | ny | k | nown or | suspected | substance |
Waste from Residues/Unused Products
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.
Contaminated Packaging
Empty remaining contents. Dispose of in accordance with local regulations. Do not re-use empty containers.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used.
Road and Rail Transport
Not Regulated
IMDG/IMO
Not regulated
IATA
Not regulated
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4-Ethylbenzophenone | - | - | - | 242-101-4 | - | - | - | - | - | - |
National Regulations
Prepared By
Health, Safety and Environmental Department
Revision Date
22-Sep-2025
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.