Chemical Safety Data Sheet MSDS / SDS
5-Chloro-2-MethoxyphenylMagnesiuM broMide, 0.50M in 2-MeTHF
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 5-Chloro-2-MethoxyphenylMagnesiuM broMide, 0.50M in 2-MeTHF
- CBnumber: CB42636427
- CAS: 419535-75-4
- Synonyms: 5-Chloro-2-MethoxyphenylMagnesium bromide;5-Chloro-2-methoxyphenylmagnesium bromide, 0.5 M in THF
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P405 Store locked up.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H225 Highly Flammable liquid and vapour
H314 Causes severe skin burns and eye damage
H318 Causes serious eye damage
Substance
- Product name: 5-Chloro-2-MethoxyphenylMagnesiuM broMide, 0.50M in 2-MeTHF
- Synonyms: 5-Chloro-2-MethoxyphenylMagnesium bromide;5-Chloro-2-methoxyphenylmagnesium bromide, 0.5 M in THF
- CAS: 419535-75-4
- MF: C7H6BrClMgO
- MW: 245.784
General Advice
Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.
Eye Contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.
Skin Contact
Wash off immediately with plenty of water for at least 15 minutes. Remove and wash contaminated clothing and gloves, including the inside, before re-use. Call a physician immediately.
Inhalation
If not breathing, give artificial respiration. Remove from exposure, lie down. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Call a physician immediately.
Ingestion
Do NOT induce vomiting. Clean mouth with water. Never give anything by mouth to an unconscious person. Call a physician immediately.
Most important symptoms and effects
Causes burns by all exposure routes. Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting: Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated: Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation
Self-Protection of the First Aider
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Notes to Physician
Treat symptomatically. Symptoms may be delayed.
Suitable Extinguishing Media
Carbon dioxide (CO2). Powder. Foam. Water may be ineffective. CO2, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used to cool closed containers.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Thermal decomposition can lead to release of irritating gases and vapors. The product causes burns of eyes, skin and mucous membranes. Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
NFPA 704
3
3
2
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal Precautions
Ensure adequate ventilation. Use personal protective equipment as required. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Remove all sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions
Should not be released into the environment. See Section 12 for additional Ecological Information. Do not allow material to contaminate ground water system. Do not flush into surface water or sanitary sewer system.
Methods for Containment and Clean Up
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.
Refer to protective measures listed in Sections 8 and 13.
Refer to protective measures listed in Sections 8 and 13.
Handling
Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Use only under a chemical fume hood. Do not breathe mist/vapors/spray. Do not ingest. If swallowed then seek immediate medical assistance. If peroxide formation is suspected, do not open or move container. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.
Take precautionary measures against static discharges.
Take precautionary measures against static discharges.
Storage
Corrosives area. Keep containers tightly closed in a dry, cool and well-ventilated place. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. Keep away from heat, sparks and flame.
Specific Use(s)
Use in laboratories
Control Parameters
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS70 General methods for sampling airborne gases and vapours MDHS 88
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography MDHS 91 Metals and metalloids in workplace air by X-ray fluorescence spectrometry MDHS 99 Metals in air by
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography MDHS 91 Metals and metalloids in workplace air by X-ray fluorescence spectrometry MDHS 99 Metals in air by
ICP-AES
Exposure Controls
Engineering Measures
Ensure that eyewash stations and safety showers are close to the workstation location. Ensure adequate ventilation, especially in confined areas. Use explosion-proof electrical/ventilating/lighting equipment. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionGoggles (European standard - EN 166)
Hand Protection
Protective gloves
Viton (R)
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Nitrile rubber | See manufacturers | - | EN 374 | (minimum requirement) |
recommendations
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Long sleeved clothing
Respiratory Protection
When workers are facing concentrations above the exposure limit they must use appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Large scale/emergency use
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: low boiling organic solvent Type AX Brown conforming to
EN371 or Organic gases and vapours filter Type A Brown conforming to EN14387
Small scale/Laboratory use
Recommended Filter type: low boiling organic solvent Type AX Brown conforming to
EN371 or Organic gases and vapours filter Type A Brown conforming to EN14387
Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141
When RPE is used a face piece Fit Test should be conducted
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141
When RPE is used a face piece Fit Test should be conducted
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
No information available.
Information on basic physicochemical properties
- Molecular Weight245.79
- Molecular FormulaC7 H6 Br ClMgO
- Oxidizing PropertiesNo information available
- Explosive PropertiesVapors may form explosive mixtures with air
- ViscosityNo data available
- Decomposition TemperatureNo data available
- Autoignition TemperatureNo data available
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsNo information available
- Water SolubilityImmiscible
- Bulk DensityNot applicable Liquid
- Specific Gravity / DensityNo data available
- Vapor DensityNo data available (Air = 1.0)
- Vapor Pressure23 hPa @ 20 °C
- Explosion LimitsNo data available
- Flammability (solid,gas)Not applicable Liquid
- Evaporation RateNo data available
- Flash Point11 °C / 12.2 °F Method - No information available
- Boiling Point/RangeNo information available
- Softening PointNo data available
- Melting Point/RangeNo data available
- pHNo information available
- Odor ThresholdNo data available
- OdorNo information available
- Physical StateLiquid
- AppearanceDark grey - Gold
Stability
Air sensitive. Moisture sensitive.
Hazardous Reactions
None under normal processing.
Hazardous Polymerization
No information available.
Conditions to Avoid
Keep away from open flames, hot surfaces and sources of ignition.
Materials to avoid
Strong bases. Oxidizing agent.
Hazardous Decomposition Products
Carbon monoxide (CO). Carbon dioxide (CO2). Hydrogen chloride. Hydrogen bromide.
Metal oxides.
Metal oxides.
Product Information
(a) acute toxicity;
Toxicology data for the components
| Component | LD50 Oral | LD50 Dermal | LC50 Inhalation |
|---|---|---|---|
| Methyltetrahydrofuran | 300-2000 mg/kg ( Rat ) | 4500 mg/kg ( Rabbit ) | 6000 ppm ( Rat ) 4 h |
(b) skin corrosion/irritation;
Category 1 B
(c) serious eye damage/irritation;
Category 1
(d) respiratory or skin sensitization;
RespiratoryNo data available
Skin
No data available
(e) germ cell mutagenicity;
No data available
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
(h) STOT-single exposure;
No data available
(i) STOT-repeated exposure;
No data available
Target Organs
No information available.
(j) aspiration hazard;
No data available
Symptoms / effects,both acute and
Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,
delayed
tiredness, nausea and vomiting: Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be
investigated
Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation
Ecotoxicity effects
May cause long-term adverse effects in the environment. Do not allow material to contaminate ground water system.
| Component | Freshwater Fish | Water Flea | Freshwater Algae | Microtox |
|---|---|---|---|---|
| Methyltetrahydrofuran | LC50 (96h) > 100 mg/l Onchorhynchus mykiss (Rainbow trout) | Chronic NOEC >=120 mg/l (21 days, Daphnia magna) | NOEC >= 104 mg/l (72h) EC50 > 104 mg/l (72h) |
Persistence and Degradability
Product contains heavy metals. Discharge into the environment must be avoided. Special pre-treatment is necessary
Persistence
May persist, based on information available.
| Component | Degradability |
|---|---|
| Methyltetrahydrofuran 96-47-9 ( 87.7 ) | (2%) 28 days |
Degradation in sewage
Contains substances known to be hazardous to the environment or not degradable in waste
treatment plant
water treatment plants.
Bioaccumulative Potential
May have some potential to bioaccumulate
Mobility in soil
Spillage unlikely to penetrate soil Is not likely mobile in the environment due its low water solubility
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging
Dispose of this container to hazardous or special waste collection point. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep product and empty container away from heat and sources of ignition.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used. Do not flush to sewer. Can be landfilled or incinerated, when in compliance with local regulations. Do not empty into drains. Large amounts will affect pH and harm aquatic organisms.
Road and Rail Transport
UN-NoUN2924
Proper Shipping Name
Flammable liquid, corrosive, n.o.s.
Technical Shipping Name
(METHYLTETRAHYDROFURAN, 5-Chloro-2-methoxyphenylmagnesium bromid)
Hazard Class
3
Subsidiary Hazard Class 8
Packing Group
Subsidiary Hazard Class 8
II
IMDG/IMO
UN-NoUN2924
Proper Shipping Name
Flammable liquid, corrosive, n.o.s.
Technical Shipping Name
(METHYLTETRAHYDROFURAN, 5-Chloro-2-methoxyphenylmagnesium bromid)
Hazard Class
3
Subsidiary Hazard Class 8
Packing Group
Subsidiary Hazard Class 8
II
IATA
UN-NoUN2924
Proper Shipping Name
Flammable liquid, corrosive, n.o.s.
Technical Shipping Name
(METHYLTETRAHYDROFURAN, 5-Chloro-2-methoxyphenylmagnesium bromid)
Hazard Class
3
Subsidiary Hazard Class
8
Packing Group
II
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methyltetrahydrofuran | X | - | X | X | 202-507-4 | X | X | X | - | X | X | KE-33479 |
National Regulations
Prepared By
Health, Safety and Environmental Department
Revision Date
28-Oct-2025
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts.
Chemical incident response training.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts.
Chemical incident response training.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Physical hazards
On basis of test data
Health Hazards
Calculation method
Environmental hazards
Calculation method
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.