11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 200.06 mg/kg (Calculation method)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Acute toxicity estimate Inhalation - 4 h - 1.36 mg/l - vapor(Calculation method)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Acute toxicity estimate Dermal - 556.75 mg/kg (Calculation method)
Skin corrosion/irritation
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
May cause sensitization by skin contact.
Mixture may cause an allergic skin reaction.
Germ cell mutagenicity
Evidence of genetic defects.
Carcinogenicity
Possible carcinogen.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture causes damage to organs. - Eyes, Central nervous system
Mixture may cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated., bronchospasm, Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting., Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., chest pain, Diffi- culty in breathing, May cause convulsions.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components formaldehyde
Acute toxicity
LD50 Oral - Rat - 100 mg/kg
Remarks: (Lit.)
Acute toxicity estimate Inhalation - 4 h - 0.51 mg/l - vapor (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
LD50 Dermal - Rabbit - 270 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 20 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: positive (OECD Test Guideline 406)
Germ cell mutagenicity
Suspected of causing genetic defects.
Carcinogenicity
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
Methanol
Acute toxicity
Acute toxicity estimate Oral - 100.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: Nausea, Vomiting
Acute toxicity estimate Inhalation - 4 h - 3.1 mg/l - vapor (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: Irritation symptoms in the respiratory tract.
Acute toxicity estimate Dermal - 300.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation
Remarks: (ECHA)
Remarks: Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
Remarks: (ECHA)
Respiratory or skin sensitization
Sensitisation test: - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Based on available data the classification criteria are not met.
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Did not show carcinogenic effects in animal experiments.
Reproductive toxicity
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
Causes damage to organs. - Eyes, Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Acute oral toxicity - Nausea, Vomiting
Acute inhalation toxicity - Irritation symptoms in the respiratory tract.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2