Chemical Safety Data Sheet MSDS / SDS
BRUCINE
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: BRUCINE
- CBnumber: CB4208446
- CAS: 5892-11-5
- EINECS Number: 628-126-7
- Synonyms: BRUCINE ALKALOID;BURCINETETRAHYDRATE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P273 Avoid release to the environment.
Hazard statements
H412 Harmful to aquatic life with long lasting effects
Substance
- Product name: BRUCINE
- Synonyms: BRUCINE ALKALOID;BURCINETETRAHYDRATE
- CAS: 5892-11-5
- EC number: 628-126-7
- MF: C23H26N2O4
- MW: 394.46
General Advice
Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.
Eye Contact
In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Skin Contact
Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.
Inhalation
Remove to fresh air. If not breathing, give artificial respiration. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required.
Ingestion
Do NOT induce vomiting. Call a physician or poison control center immediately.
Most important symptoms and effects
None reasonably foreseeable.
Self-Protection of the First Aider
No special precautions required.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Carbon dioxide (CO2). Powder. Water spray. In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Thermal decomposition can lead to release of irritating gases and vapors.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
NFPA 704
4
1
0
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal Precautions
Ensure adequate ventilation. Use personal protective equipment as required. Avoid dust formation. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas.
Environmental Precautions
Should not be released into the environment. Avoid release to the environment. Collect spillage. See Section 12 for additional
Ecological Information. Do not flush into surface water or sanitary sewer system.
Ecological Information. Do not flush into surface water or sanitary sewer system.
Methods for Containment and Clean Up
Sweep up and shovel into suitable containers for disposal. Avoid dust formation.
Refer to protective measures listed in Sections 8 and 13.
Refer to protective measures listed in Sections 8 and 13.
Handling
Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Avoid dust formation. Use only under a chemical fume hood. Do not breathe (dust, vapor, mist, gas). Do not ingest. If swallowed then seek immediate medical assistance.
Storage
Keep container tightly closed in a dry and well-ventilated place.
Specific Use(s)
Use in laboratories
Control Parameters
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS14/3 General methods for sampling and gravimetric analysis of respirable and inhalable dust
Exposure Controls
Engineering Measures
Ensure adequate ventilation, especially in confined areas. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionWear safety glasses with side shields (or goggles) (European standard - EN 166)
Hand Protection
Protective gloves
Glove material Breakthrough time Glove thickness EU standard
Glove comments
Nitrile rubber 480 minutes 0.11mm EN 374
(minimum requirement)
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Long sleeved clothing
Respiratory Protection
When workers are facing concentrations above the exposure limit they must use appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Large scale/emergency use
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
In case of insufficient ventilation, wear suitable respiratory equipment
Recommended Filter type: Particulates filter conforming to EN 143
Small scale/Laboratory use
Recommended Filter type: Particulates filter conforming to EN 143
Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
When RPE is used a face piece Fit Test should be conducted
When RPE is used a face piece Fit Test should be conducted
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
Prevent product from entering drains.
Information on basic physicochemical properties
- Water solubilitySoluble in methanol. Partially soluble Miscible with water.
- Molecular Weight430.50 (394.47anhy)
- Molecular FormulaC23 H26 N2 O4.2H2 O
- Oxidizing PropertiesNo information available
- Explosive PropertiesNo information available
- ViscosityNot applicable Solid
- Decomposition TemperatureNo data available
- Autoignition TemperatureNo data available
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsNo information available
- Water SolubilitySoluble in methanol. Partially soluble Miscible with water.
- Bulk DensityNo data available
- Specific Gravity / DensityNo data available
- Vapor DensityNot applicable Solid
- Vapor PressureNo data available
- Explosion LimitsNo data available
- Flammability (solid,gas)No information available
- Evaporation RateNot applicable Solid
- Flash PointNo information available
Method - No information available - Boiling Point/RangeNo information available
- Softening PointNo data available
- Melting Point/Range176 - 178 °C / 348.8 - 352.4 °F
- pHNo information available
- Odor ThresholdNo data available
- OdorNo information available
- Physical StateSolid
- AppearanceNo information available
Stability
Stable under normal conditions.
Hazardous Reactions
None under normal processing.
Hazardous Polymerization
No information available.
Conditions to Avoid
None known.
Materials to avoid
Oxidizing agent.
Hazardous Decomposition Products
None under normal use conditions.
Product Information
(a) acute toxicity;
(b) skin corrosion/irritation;
No data available
(c) serious eye damage/irritation;
No data available
(d) respiratory or skin sensitization;
RespiratoryNo data available
Skin
No data available
(e) germ cell mutagenicity;
No data available
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
(h) STOT-single exposure;
No data available
(i) STOT-repeated exposure;
No data available
Target Organs
No information available.
(j) aspiration hazard;
Not applicable
Solid
Solid
Symptoms / effects,both acute and delayed
No information available
Ecotoxicity effects
Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product contains following substances which are hazardous for the environment.
Persistence and Degradability
No information available
Degradation in sewage
Contains substances known to be hazardous to the environment or not degradable in waste
treatment plant
water treatment plants.
Bioaccumulative Potential
No information available
Mobility in soil
No information available
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging
Dispose of this container to hazardous or special waste collection point.
Other Information
Do not flush to sewer. Waste codes should be assigned by the user based on the application for which the product was used. Do not empty into drains. Do not let this chemical enter the environment.
Road and Rail Transport
UN-NoUN1570
Proper Shipping Name
BRUCINE
Hazard Class
6.1
Packing Group
I
IMDG/IMO
UN-NoUN1570
Proper Shipping Name
BRUCINE
Hazard Class
6.1
Packing Group
I
IATA
UN-NoUN1570
Proper Shipping Name
BRUCINE
Hazard Class
6.1
Packing Group
I
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brucine dihydrate, (-)- | - | - | X | - | - | - | - | X | - | - | - |
National Regulations
Prepared By
Health, Safety and Environmental Department
Revision Date
23-Sep-2025
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.