Chemical Safety Data Sheet MSDS / SDS

Carboxypeptidase A

Revision Date:2026-09-12Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Carboxypeptidase A
CBnumber: CB1776427
CAS: 11075-17-5
EINECS Number: 234-297-5
Synonyms: carboxypeptidase A,Carboxypeptidase A from bovine pancreas

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P284 Wear respiratory protection.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Hazard statements

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

SECTION 3: Composition/information on ingredients

Substance

Product name: Carboxypeptidase A
Synonyms: carboxypeptidase A,Carboxypeptidase A from bovine pancreas
CAS: 11075-17-5
EC number: 234-297-5
MF: NULL

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

4.4 Notes to physician

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

Nature of decomposition products not known.

5.3 Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.

Hygiene measures

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Storage stabilityRecommended storage temperature

2 - 8 °C

Storage class

Storage class (TRGS 510): 10: Combustible liquids

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis']	['Toluene', '108-88-3', 'PC-TWA', '50 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.']	['', 'Remarks', 'Skin', None, None]	['', '', 'PC-STEL', '100 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.']	['', '', 'Skin', None, None]

Biological occupational exposure limits

['Component', 'CAS-No.', 'Parameters', 'Value', 'Biological\nspecimen', 'Basis']	['', '108-88-3', 'hippuric', '1mol/mo', 'Urine', 'China. Biological']
['', 'Remarks', 'End of workshift (after exposure has ended)', None, None, None]	['', '', 'hippuric\nacid', '1.5g/g\ncreatinin\ne', 'Urine', 'China. Biological\nOccupational\nExposure Indices']	['', '', 'End of workshift (after exposure has ended)', None, None, None]	['', '', 'hippuric\nacid', '11Millim\noles per\nliter', 'Urine', 'China. Biological\nOccupational\nExposure Indices']	['', '', 'End of workshift (after exposure has ended)', None, None, None]	['', '', 'hippuric\nacid', '2 g/l', 'Urine', 'China. Biological\nOccupational\nExposure Indices']	['', '', 'End of workshift (after exposure has ended)', None, None, None]	['', '', 'toluene', '20mg/m\n³', 'end exhaled air', 'China. Biological\nOccupational\nExposure Indices']	['', '', 'End of workshift (15-30 min after exposure has ended)', None, None, None]	['', '', 'toluene', '5mg/m³', 'end exhaled air', 'China. Biological\nOccupational\nExposure Indices']	['', '', 'Prior to shift', None, None, None]

acid l Occupational creatinin Exposure Indices e

8.2 Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Splash contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

a) Physical statesuspension
b) Colorwhite
c) OdorNo data available
d) Melting point/freezing pointNo data available
e) Initial boiling point and boiling rangeNo data available
f) Flammability (solid, gas)No data available
g) Upper/lower flammability or explosive limitsNo data available
h) Flash point4 °C
i) Autoignition temperatureNo data available
j) Decomposition temperatureNo data available
k) pHNo data available
l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available
m) Water solubilityNo data available
n) Partition coefficient n-octanol/waterNo data available
o) Vapor pressureNo data available
p) Density1.000 g/cm3
Relative density1.00 g/mL at 20 °C
q) Relative vapor densityNo data available
r) Particle characteristicsNo data available
s) Explosive propertiesNot classified as explosive.
t) Oxidizing propertiesnone

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Chemical stability

Stable under recommended storage conditions.

10.2 Possibility of hazardous reactions

No data available

10.3 Conditions to avoid

No data available

10.4 Incompatible materials

Oxidizing agents, Strong oxidizing agents

10.5 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture Acute toxicity

Oral: No data available
Inhalation: No data available
Dermal: No data available

Skin corrosion/irritation

Classified based on available data. For more details, see section 2

Serious eye damage/eye irritation

Classified based on available data. For more details, see section 2

Respiratory or skin sensitization

Classified based on available data. For more details, see section 2

Germ cell mutagenicity

Classified based on available data. For more details, see section 2

Carcinogenicity

Classified based on available data. For more details, see section 2

Reproductive toxicity

Classified based on available data. For more details, see section 2

Specific target organ toxicity - single exposure

Classified based on available data. For more details, see section 2

Specific target organ toxicity - repeated exposure

Classified based on available data. For more details, see section 2

Aspiration hazard

Classified based on available data. For more details, see section 2

11.2 Additional Information

Lung irritation, chest pain, pulmonary edema, Inhalation studies on toluene have demonstrated the development of inflammatory and ulcerous lesions of the penis, prepuce, and scrotum in animals.

Components carboxypeptidase A (from bovine pancreas)

Acute toxicity

Oral: No data available
Inhalation: No data available
Dermal: No data available

Skin corrosion/irritation

Remarks: No data available

Serious eye damage/eye irritation

Remarks: No data available

Respiratory or skin sensitization

Classified based on available data. For more details, see section 2

Germ cell mutagenicity

Classified based on available data. For more details, see section 2

Carcinogenicity

Classified based on available data. For more details, see section 2

Reproductive toxicity

Classified based on available data. For more details, see section 2

Specific target organ toxicity - single exposure

May cause respiratory irritation.

Specific target organ toxicity - repeated exposure

Classified based on available data. For more details, see section 2

Aspiration hazard

Classified based on available data. For more details, see section 2

Toluene Acute toxicity

LD50 Oral - Rat - male - 5,580 mg/kg (Directive 67/548/EEC, Annex V, B.1.)
LC50 Inhalation - Rat - male - 4 h - 25.7 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - > 5,000 mg/kg
Remarks: (ECHA)

Skin corrosion/irritation

Skin - Rabbit
Result: irritating - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)

Respiratory or skin sensitization

Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)

Germ cell mutagenicity

Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Species: Rat - Bone marrow
Result: negative
Remarks: (ECHA)

Carcinogenicity

Classified based on available data. For more details, see section 2

Reproductive toxicity

Suspected of damaging the unborn child.

Specific target organ toxicity - single exposure

Inhalation - May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Specific target organ toxicity - repeated exposure

Inhalation - May cause damage to organs through prolonged or repeated exposure.
- Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Aspiration hazard

Aspiration may cause pulmonary edema and pneumonitis.

SECTION 12: Ecological information

12.1 Toxicity

Mixture

No data available

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

No data available

Components carboxypeptidase A (from bovine pancreas)

No data available

Toluene

Toxicity to fish flow-through test LC50 - Oncorhynchus kisutch (coho salmon) - 5.5 mg/l - 96 h
Remarks: (ECHA)
Toxicity to daphnia EC50 - Ceriodaphnia dubia (water flea) - 3.78 mg/l - 48 h and other aquatic (US-EPA) invertebrates
Toxicity to bacteria static test EC50 - Bacteria - 84 mg/l - 24 h
Remarks: (ECHA)
Toxicity to flow-through test NOEC - Oncorhynchus kisutch (coho salmon) fish(Chronic toxicity) - 1.39 mg/l - 40 d
Remarks: (ECHA)
Toxicity to daphnia NOEC - Ceriodaphnia dubia (water flea) - 0.74 mg/l - 7 d and other aquatic (US-EPA) invertebrates(Chronic toxicity)

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product
Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number

ADR/RID: -
IMDG: -
IATA-DGR: -

14.2 UN proper shipping name

ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods

14.3 Transport hazard class(es)

ADR/RID: -
IMDG: -
IATA-DGR: -

14.4 Packaging group

ADR/RID: -
IMDG: -
IATA-DGR: -

14.5 Environmental hazards

ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no

14.6 Special precautions for user

14.7 Incompatible materials

Oxidizing agents, Strong oxidizing agents
Further information: Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

National regulatory information
Law on the Prevention and Control of Occupational Diseases
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222211049
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.