11.1 Information on toxicological effects
Mixture Acute toxicity
Acute toxicity estimate Oral - 4,646 mg/kg (Calculation method)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components glycerine
Acute toxicity
LD50 Oral - Rat - female - 27,200 mg/kg
Remarks: (ECHA)
LC50 Inhalation - Rat - male and female - 4 h - > 5,850 mg/l - aerosol
Remarks: (ECHA)
LD50 Dermal - Guinea pig - male and female - 56,750 mg/kg
Remarks: (ECHA)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 24 h
Remarks: (ECHA)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 7 Days
Remarks: (ECHA)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Remarks: (IUCLID)
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Result: negative
Test Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
1,4-dimercaptobutane-2,3-diol
Acute toxicity
LD50 Oral - Rat - 400 mg/kg
Remarks: (External MSDS)
The value is given in analogy to the following substances: (R*,R*)-1,4-
Dimercapto-2,3-butanediol
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Imidazole
Acute toxicity
LD50 Oral - Rat - 970 mg/kg (OECD Test Guideline 401)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Corrosive after 1 to 4 hours of exposure - 4 h (OECD Test Guideline 404)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye damage.
(OECD Test Guideline 405)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Result: negative
Test Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage the unborn child.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Oral - Liver, Kidney
Aspiration hazard
Classified based on available data. For more details, see section 2