Chemical Safety Data Sheet MSDS / SDS
Tobramycin sulfate
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: Tobramycin sulfate
- CBnumber: CB0475411
- CAS: 49842-07-1
- EINECS Number: 256-499-2
- Synonyms: obracine ;tenemicin
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P330 Rinse mouth.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Hazard statements
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Substance
- Product name: Tobramycin sulfate
- Synonyms: obracine ;tenemicin
- CAS: 49842-07-1
- EC number: 256-499-2
- MF: C18H39N5O13S
- MW: 565.59
Description of first aid measures
General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
After inhalation
Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptoms persist.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Generally the product does not irritate the skin.
After eye contact
Rinse opened eye for several minutes under running water.
After swallowing
If symptoms persist consult doctor.
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.
A solid water stream may be inefficient.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
Mouth respiratory protective device.
Personal precautions, protective equipment and emergency procedures
Not required.
Environmental precautions
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Ensure adequate ventilation.
Protective Action Criteria for Chemicals
PAC-1
Substance is not listed.
PAC-2
Substance is not listed.
PAC-3
Substance is not listed.
Substanceis not listed.
Reference to other sections
See Section 7 for informationon safe handling.
See Section 8 for informationon personal protection equipment.
See Section 13 fordisposalinfor mation.
Substanceis not listed.
Reference to other sections
See Section 7 for informationon safe handling.
See Section 8 for informationon personal protection equipment.
See Section 13 fordisposalinfor mation.
Precautions for safe handling
Thorough dedusting.
Ensure good ventilation/exhaustion at the workplace.
Ensure good ventilation/exhaustion at the workplace.
Information about protection against explosions and fires
No special measures required.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Specific end use(s)
No further relevant information available.
Control parameters
Components with limit values that require monitoring at the workplace
Not required.
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Appropriate engineering controls
No further data; see section 7.
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Not required.
Information on basic physicochemical properties
- Water solubilitySoluble in water (50 mg/ml).
- Physical StateSolid
- ColorWhite to off-white
- OdorCharacteristic
- Structural FormulaC18H37N5O9 5/2H2SO4
- Molecular Weight712.7 g/mol
- Odor ThresholdNot determined.
- Melting point/Melting rangeUndetermined.
- Boiling point/Boiling rangeUndetermined.
- FlammabilityProduct is not flammable.
- Explosion limitsLower: Not determined.
Upper: Not determined. - Flash pointNot applicable.
- Decomposition temperatureNot determined.
- pHNot applicable.
- KinematicNot applicable.
- SOLUBILITYPBS (pH 7.2): Soluble: =10 mg/ml
- DynamicNot applicable.
- Solubility in / Miscibility withMethanol (Slightly), Water (Sparingly)
- WaterNot determined.
- Partition coefficient (n-octanol/water)Not determined.
- Vapor PressureNot applicable.
- DensityNot determined.
- Relative DensityNot determined.
- Vapor DensityNot applicable.
- Particle characteristicsNot determined.
- FormSolid
- Ignition temperatureNot determined.
- Danger of explosionProduct does not present an explosion hazard.
- Evaporation RateNot applicable.
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
No further relevant information available.
Hazardous decomposition products
No dangerous decomposition products known.
RTECS Number
WK2110000
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Route | Endpoint | Value |
|---|---|---|
| Oral | LD50 | >10,500 mg/kg (mouse) |
| Intraperitoneal | LD50 | 262 mg/kg (mouse) |
| Subcutaneous | LD50 | 1,680 mg/kg (rat) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
Interactive effects
No interactive effects between components are known.
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Alternative sources for toxicological information
No non-standard sources for toxicological information where used.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Results of PBT and vPvB assessment
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
Additional ecological information
General notes
Water hazard class 1 (Self-assessment) slightly hazardous for water
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
UN-Number
DOT, IMDG, IATA not regulated
UN proper shipping name
DOT, IMDG, IATA not regulated
Transport hazard class(es)
DOT, ADN, IMDG, IATA
Class not regulated
Class not regulated
Packing group
DOT, IMDG, IATA not regulated
Environmental hazards
Not applicable.
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
MARPOL73/78 and the IBC Code Not applicable.
UN "Model Regulation"
not regulated
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is not listed. |
| Section 313 (Specific toxic chemical listings): | Substance is not listed. |
| TSCA (Toxic Substances Control Act): | Substance is not listed. |
| Hazardous Air Pollutants: | Substance is not listed. |
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is listed. |
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute toxicity - dermal 4: Acute toxicity – Category 4
Reproductive toxicity 1B: Reproductive toxicity – Category 1B
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute toxicity - dermal 4: Acute toxicity – Category 4
Reproductive toxicity 1B: Reproductive toxicity – Category 1B
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.