Chemical Safety Data Sheet MSDS / SDS
Dimethyl acetylsuccinate
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Dimethyl acetylsuccinate
- CBnumber: CB0421498
- CAS: 10420-33-4
- EINECS Number: 233-897-4
- Synonyms: DIMETHYL ACETYLSUCCINATE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H315 Causes skin irritation
H302 Harmful if swallowed
Substance
- Product name: Dimethyl acetylsuccinate
- Synonyms: DIMETHYL ACETYLSUCCINATE
- CAS: 10420-33-4
- EC number: 233-897-4
- MF: C8H12O5
- MW: 188.18
4.1 Description of first-aid measures
If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
5.1 Extinguishing media
Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
NFPA 704
0
1
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapors, mist or gas.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
No special environmental precautions required.
6.3 Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on protection against fire and explosionProvide appropriate exhaust ventilation at places where dust is formed.
Hygiene measures
General industrial hygiene practice.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsStore in cool place. Keep container tightly closed in a dry and well-ventilated place.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
8.1 Control parameters
Ingredients with workplace control parameters8.2 Exposure controls
Personal protective equipmentEye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
No special environmental precautions required.
Information on basic physicochemical properties
- a) AppearanceForm: solid
Color: colorless, yellow - b) OdorNo data available
- c) Odor ThresholdNo data available
- d) pHNo data available
- e) Melting point/freezing pointMelting point/range: 33 °C - lit.
- f) Initial boiling point and boiling range129 - 134 °C at 16 hPa - lit.
- g) Flash point138 °C - closed cup - ISO 2719
- h) Evaporation rateNo data available
- i) Flammability (solid, gas)No data available
- j) Upper/lower flammability or explosive limits0.72-11.1%(V)
- k) Vapor pressure19.6Pa at 25℃
- l) Vapor densityNo data available
- m) Relative density1,31 at 20,1 °C - OECD Test Guideline 109
- n) Water solubility56,2 g/l at 20 °C - OECD Test Guideline 105- completely soluble
- o) Partition coefficient n-octanol/waterlog Pow: 0,69 at 35 °C
- p) Autoignition temperatureNo data available
- q) Decomposition temperature270 °C -
- r) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - s) Explosive propertiesNo data available
- t) Oxidizing propertiesNo data available
- Solubility30g/l OECD Test Guideline 105
- Physical statesolid
- ColourWhite or Colorless to Almost white or Almost colorless
9.2 Other safety information
No data available
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents, Strong bases
10.6 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 401)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Maximization Test - Guinea pig
Result: Does not cause skin sensitization.
(OECD Test Guideline 406)
Germ cell mutagenicity
Result: Does not cause skin sensitization.
(OECD Test Guideline 406)
Ames test
S. typhimurium
Result: negative
Carcinogenicity
S. typhimurium
Result: negative
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Not available
12.1 Toxicity
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 79,36 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test EC50 - Pseudokirchneriella subcapitata - > 100 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to algae static test EC50 - Pseudokirchneriella subcapitata - > 100 mg/l - 72 h (OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 94,49 % - Readily biodegradable.
(OECD Test Guideline 301B)
Result: 94,49 % - Readily biodegradable.
(OECD Test Guideline 301B)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Offer surplus and non-recyclable solutions to a licensed disposal company.
Dispose of as unused product.
14.1 UN number
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA: no
IMDG Marine pollutant: no
IATA: no
14.6 Special precautions for user
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the : Not applicable
European Parliament and of the Council on the control of major-accident hazards involving dangerous substances.
1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the : Not applicable
European Parliament and of the Council on the control of major-accident hazards involving dangerous substances.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.