Chemical Safety Data Sheet MSDS / SDS
Ethyl acetoacetate
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Ethyl acetoacetate
- CBnumber: CB0301721
- CAS: 141-97-9
- EINECS Number: 205-516-1
- Synonyms: ETHYL 3-OXOBUTANOATE;EAA
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P501 Dispose of contents/container to..…
P403+P235 Store in a well-ventilated place. Keep cool.
P370+P378 In case of fire: Use … for extinction.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Hazard statements
H227 Combustible liquid
H319 Causes serious eye irritation
H303 May be harmfulif swallowed
Substance
- Product name: Ethyl acetoacetate
- Synonyms: ETHYL 3-OXOBUTANOATE;EAA
- CAS: 141-97-9
- EC number: 205-516-1
- MF: C6H10O3
- MW: 130.14
4.1 Description of first-aid measures
If inhaledAfter inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaWater Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
1
2
0
| HEALTH | 1 | Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g.
Chemizorb® H⁺, Merck Art. No. 101595). Dispose of properly. Clean up affected area.
Chemizorb® H⁺, Merck Art. No. 101595). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed.
Storage class
Storage class (TRGS 510): 10: Combustible liquids
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsChange contaminated clothing. Wash hands after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 30 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 30 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Respiratory protection
Not required; except in case of aerosol formation.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) Colorcolorless
- c) Odorcharacteristic, ester-like
- d) Melting point/freezing pointMelting point/range: -43 °C - lit.
- e) Initial boiling point and boiling range181 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsUpper explosion limit: 9.5 %(V)
Lower explosion limit: 1.4 %(V) - h) Flash point73.5 °C - closed cup - ISO 2719
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pH4.0 at 110 g/l at 20 °C
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: 1.696 mPa.s at 20 °C - OECD Test Guideline 114 - m) Water solubilitysoluble 130.3 g/l at 20 °C - OECD Test Guideline 105- completely
- n) Partition coefficient n-octanol/waterlog Pow: 0.8 at 20 °C - OECD Test Guideline 117 -
Bioaccumulation is not expected. - o) Vapor pressure0.26 hPa at 20 °C - OECD Test Guideline 104 0.42 hPa at 25 °C - OECD Test Guideline 104 3.5 hPa at 50 °C - OECD Test Guideline 104
- p) Density1.029 g/cm3 at 20 °C - lit.
- Relative density1.03 at 20 °C - OECD Test Guideline 109
- q) Relative vapor density4.49 - (Air = 1.0)
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- Solubility116 g/L (20°C)
- Dielectric constant15.0（Ambient）
9.2 Other safety information
Relative vapor density4.49 - (Air = 1.0)
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
Strong acids
Strong bases
Strong oxidizing agents
Strong acids
Strong bases
10.3 Conditions to avoid
Strong heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - female - 10,800 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rabbit - male and female - 4 h - > 49.2 mg/l - vapor
Remarks: (ECHA)
The value is given in analogy to the following substances: methyl acetate
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
LC50 Inhalation - Rabbit - male and female - 4 h - > 49.2 mg/l - vapor
Remarks: (ECHA)
The value is given in analogy to the following substances: methyl acetate
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Eyes - Rabbit
Result: No eye irritation - 24 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation - 24 h (OECD Test Guideline 405)
Freund's complete adjuvant test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Carcinogenicity
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 28 d - NOAEL (No observed adverse effect level) - 1,000 mg/kg
Remarks: Subacute toxicity
No significant adverse effects were reported
RTECS: AK5250000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Headache
Dizziness
Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Remarks: Subacute toxicity
No significant adverse effects were reported
RTECS: AK5250000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Headache
Dizziness
Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to fish semi-static test LC50 - Danio rerio (zebra fish) - > 100 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 100 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 100 mg/l - 72 h (OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability aerobic Chemical oxygen demand - Exposure time 28 d
Result: 66 % - Readily biodegradable.
(OECD Test Guideline 301D)
Result: 66 % - Readily biodegradable.
(OECD Test Guideline 301D)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.