11.1 Information on toxicological effects
Mixture Acute toxicity
Acute toxicity estimate Oral - > 5,000 mg/kg (Calculation method)
Acute toxicity estimate Inhalation - 4 h - > 40 mg/l - vapor(Calculation method)
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Possible mutagen
Carcinogenicity
Possible carcinogen.
Reproductive toxicity
May harm the unborn child.
May impair fertility.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Components dimethyl sulphoxide
Acute toxicity
LD50 Oral - Rat - male and female - 28,300 mg/kg (OECD Test Guideline 401)
LC0 Inhalation - Rat - male and female - 4 h - > 5.33 mg/l - dust/mist (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - 40,000 mg/kg
Remarks: (ECHA)
Skin corrosion/irritation
Skin - Rabbit
Result: slight irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: slight irritation - 24 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Method: OECD Test Guideline 474
Species: Rat - male and female
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
ethylene oxide Acute toxicity
Acute toxicity estimate Oral - 100 mg/kg (Expert judgment)
Acute toxicity estimate Inhalation - 700 ppm - gas (Expert judgment)
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 1 - 60 min
Remarks: (ECHA)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
May cause genetic defects.
Carcinogenicity
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Suspected of damaging the unborn child.
May damage fertility.
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
May cause drowsiness or dizziness. - Nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Causes damage to organs through prolonged or repeated exposure.
- Nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
Classified based on available data. For more details, see section 2