Chemical Safety Data Sheet MSDS / SDS
FLURAZEPAM
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: FLURAZEPAM
- CBnumber: CB6157449
- CAS: 17617-23-1
- EINECS Number: 241-591-7
- Synonyms: D00329;Felmane
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P403+P235 Store in a well-ventilated place. Keep cool.
P370+P378 In case of fire: Use … for extinction.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H370 Causes damage to organs
H225 Highly Flammable liquid and vapour
Substance
- Product name: FLURAZEPAM
- Synonyms: D00329;Felmane
- CAS: 17617-23-1
- EC number: 241-591-7
- MF: C21H23ClFN3O
- MW: 387.88
Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
After inhalation
Supply fresh air or oxygen; call for doctor.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing
Do not induce vomiting; immediately call for medical help.
Information for doctor
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
FIRE-FIGHTING MEASURES
| Fire-fighting measure | Details |
|---|---|
| Suitable extinguishing agents | CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. |
| Special hazards arising from the substance or mixture | 67-56-1During heating or in case of fire poisonous gases are produced. |
| Protective equipment | Mouth respiratory protective device. |
NFPA 704
0
3
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Mount respiratory protective device.
Wear protective equipment. Keep unprotected persons away.
Wear protective equipment. Keep unprotected persons away.
Environmental precautions
Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Protective Action Criteria for Chemicals
PAC-1
67-56-1 Methanol 530 ppm
PAC-2
67-56-1 Methanol 2,100 ppm
PAC-3
67-56-1 Methanol 7200* ppm
Handling
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
Prevent formation of aerosols.
Open and handle receptacle with care.
Prevent formation of aerosols.
Information about protection against explosions and fires
Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
Keep respiratory protective device available.
Protect against electrostatic charges.
Keep respiratory protective device available.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
Store in a cool location.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Store in cool, dry conditions in well sealed receptacles.
Store in cool, dry conditions in well sealed receptacles.
Specific end use(s)
No further relevant information available.
Additional information about design of technical systems
No further data; see section 7.
Control parameters
Components with limit values that require monitoring at the workplace:
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
| 67-56-1 Methanol | |
|---|---|
| PEL | Long-term value: 260 mg/m³, 200 ppm |
| REL | Short-term value: 325 mg/m³, 250 ppm Long-term value: 260 mg/m³, 200 ppm Skin |
| TLV | Short-term value: 250 ppm Long-term value: 200 ppm Skin; BEIc |
| Ingredients with biological limit values: | |
| 67-56-1 Methanol | |
|---|---|
| BEI | 15 mg/L Medium: urine Time: end of shift Parameter: Methanol (background, nonspecific) |
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Tightly sealed goggles
Information on basic physicochemical properties
- Partition coefficient (n-octanol/water)Not determined.
- Water at 20 °C (68 °F)1000 g/l
- Solubility in / Miscibility with45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <6 mg/mL
- Evaporation RateNot determined.
- Vapor DensityNot determined.
- Relative Density1.2089 (estimate)
- Density at 20 °C (68 °F)0.79 g/cm³ (6.59255 lbs/gal)
- Vapor Pressure at 20 °C (68 °F)128 hPa (96 mm Hg)
- Explosion limitsLower: 5.5 Vol %
Upper: 44 Vol % - Danger of explosionProduct is not explosive. However, formation of explosive air/ vapor mixtures are possible.
- Ignition temperatureProduct is not selfigniting.
- Decomposition temperatureNot determined.
- Auto igniting455 °C (851 °F)
- Flammability (solid,gas)Highly flammable.
- Flash point9.7 °C (49.5 °F)
- Boiling point/Boiling range64.7 °C (148.5 °F)
- Melting point/Melting range-98 °C (-144.4 °F)
- pHNot determined.
- FormulationA solution in methanol
- Odor ThresholdNot determined.
- Molecular Weight387.9 g/mol
- Structural FormulaC21H23ClFN3O
- OdorAlcohol-like
- ColorAccording to product specification
- Physical StateLiquid
- Other informationNo information available
- Solids content2.5 %
- VOC content97.50 % 975.0 g/l / 8.14 lb/gal
- Organic solvents97.5 %
- KinematicNot determined.
- DynamicNot determined.
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
No further relevant information available.
Hazardous decomposition products
No dangerous decomposition products known.
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Substance / Estimate | Route | Endpoint | Value |
|---|---|---|---|
| ATE (Acute Toxicity Estimate) | Oral | LD50 | 102 mg/kg |
| ATE (Acute Toxicity Estimate) | Dermal | LD50 | 308 mg/kg (rabbit) |
| ATE (Acute Toxicity Estimate) | Inhalative | LC50/4 h | 3.18 mg/l (rat) |
| 67-56-1 Methanol | Oral | LD50 | 100.1 mg/kg (rat) (Expert judgment) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Symptoms: Nausea, Vomiting |
| 67-56-1 Methanol | Dermal | LD50 | 300.1 mg/kg (rabbit) (Expert judgment) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) |
| 67-56-1 Methanol | Inhalative | LC50/4 h | 3.1 mg/l (rat) (Expert judgment) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Symptoms: Irritation symptoms in the respiratory tract. |
| 17617-23-1 Flurazepam | Oral | LD50 | 500 mg/kg (mouse) 980 mg/kg (rat) |
| 17617-23-1 Flurazepam | Oral | TDLO | 380 µg/kg (human) |
| 17617-23-1 Flurazepam | Intraperitoneal | LD50 | 540 mg/kg (mouse) 600 mg/kg (rat) |
| 17617-23-1 Flurazepam | Subcutaneous | LD50 | 3,844 mg/kg (mouse) >3,844 mg/kg (rat) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
The product shows the following dangers according to internally approved calculation methods for preparations
Toxic
Toxic
Carcinogenic categories
IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
NTP (National Toxicology Program)
None of the ingredients is listed.
OSHA-Ca (Occupational Safety & Health Administration)
None of the ingredients is listed.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Behavior in environmental systems
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Additional ecological information
General notes
Water hazard class 2 (Self-assessment) hazardous for water
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
Recommended cleansing agent
Water, if necessary with cleansing agents.
UN-Number
DOT, IMDG, IATA UN1992
UN proper shipping name
DOT Flammable liquids, toxic, n.o.s. (Methanol)
IMDG FLAMMABLE LIQUID, TOXIC, N.O.S. (Methanol)
IATA Flammable liquid, toxic, n.o.s. (Methanol)
IMDG FLAMMABLE LIQUID, TOXIC, N.O.S. (Methanol)
IATA Flammable liquid, toxic, n.o.s. (Methanol)
Transport hazard class(es)
DOTClass: 3 Flammable liquids
Label: 3, 6.1
IMDG
Label: 3, 6.1
Class: 3 Flammable liquids
Label: 3/6.1
IATA
Label: 3/6.1
Class: 3 Flammable liquids
Label: 3 (6.1)
Label: 3 (6.1)
Packing group
DOT, IMDG, IATA II
Environmental hazards
Not applicable.
Special precautions for user
Warning: Flammable liquids
Hazard identification number (Kemler code)
336
EMS Number
F-E,S-D
Stowage Category
B
Stowage Code
SW2 Clear of living quarters.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 1 L
On cargo aircraft only: 60 L
On cargo aircraft only: 60 L
IMDG:
Limited quantities (LQ)
1L
Excepted quantities (EQ)
Code: E2
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
UN "Model Regulation"
UN 1992 FLAMMABLE LIQUID, TOXIC, N.O.S.
(METHANOL), 3 (6.1), II
(METHANOL), 3 (6.1), II
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | None of the ingredients is listed. |
| Section 313 (Specific toxic chemical listings): | 67-56-1 Methanol |
| TSCA (Toxic Substances Control Act): | 67-56-1 Methanol ACTIVE |
| Hazardous Air Pollutants 67-56-1 Methanol | |
Proposition 65
| Chemicals known to cause cancer: | None of the ingredients is listed. |
| Chemicals known to cause reproductive toxicity for females: | None of the ingredients is listed. |
| Chemicals known to cause reproductive toxicity for males: | None of the ingredients is listed. |
| Chemicals known to cause developmental toxicity: | All ingredients are listed. |
Carcinogenic categories
| EPA (Environmental Protection Agency): | None of the ingredients is listed. |
TLV (Threshold Limit Value)
None of the ingredients is listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
None of the ingredients is listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
BEI: Biological Exposure Limit
Flammable Liquids 2: Flammable liquids – Category 2
Acute Toxicity - Oral 3: Acute toxicity – Category 3
Specific Target Organ Toxicity - Single Exposure 1: Specific target organ toxicity (single exposure) – Category 1
Specific Target Organ Toxicity - Repeated Exposure 2: Specific target organ toxicity (repeated exposure) – Category 2
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
BEI: Biological Exposure Limit
Flammable Liquids 2: Flammable liquids – Category 2
Acute Toxicity - Oral 3: Acute toxicity – Category 3
Specific Target Organ Toxicity - Single Exposure 1: Specific target organ toxicity (single exposure) – Category 1
Specific Target Organ Toxicity - Repeated Exposure 2: Specific target organ toxicity (repeated exposure) – Category 2
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.