Chemical Safety Data Sheet MSDS / SDS
HYDROCODONE BITARTRATE
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: HYDROCODONE BITARTRATE
- CBnumber: CB9473263
- CAS: 143-71-5
- EINECS Number: 205-608-1
- Synonyms: Dicodrine;Dicotrate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P501 Dispose of contents/container to..…
P330 Rinse mouth.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
Hazard statements
H302 Harmful if swallowed
Substance
- Product name: HYDROCODONE BITARTRATE
- Synonyms: Dicodrine;Dicotrate
- CAS: 143-71-5
- EC number: 205-608-1
- MF: C22H27NO9
- MW: 449.45
Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
After inhalation
Supply fresh air or oxygen; call for doctor.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing
If symptoms persist consult doctor.
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
FIRE-FIGHTING MEASURES
| Fire-fighting measure | Details |
|---|---|
| Suitable extinguishing agents | Use fire fighting measures that suit the environment. A solid water stream may be inefficient. |
| Special hazards arising from the substance or mixture | No further relevant information available. |
| Protective equipment | Mouth respiratory protective device. |
NFPA 704
2
0
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Not required.
Environmental precautions
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Protective Action Criteria for Chemicals
PAC-1
Substance is not listed.
PAC-2
Substance is not listed.
PAC-3
Substance is not listed.
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
Open and handle receptacle with care.
Information about protection against explosions and fires
Keep respiratory protective device available.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Specific end use(s)
No further relevant information available.
Control parameters
Components with limit values that require monitoring at the workplace
Not required.
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Appropriate engineering controls
No further data; see section 7.
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Goggles recommended during refilling.
Information on basic physicochemical properties
- Evaporation RateNot determined.
- Danger of explosionProduct does not present an explosion hazard.
- Ignition temperatureNot determined.
- FormFluid
- Particle characteristicsNot applicable.
- Vapor DensityNot determined.
- Relative DensityNot determined.
- DensityNot determined.
- Vapor PressureNot determined.
- Partition coefficient (n-octanol/water)Not determined.
- WaterNot determined.
- Solubility in / Miscibility withH2O: 62 mg/mL
- DynamicNot determined.
- SOLUBILITYDMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- KinematicNot determined.
- pHNot determined.
- Decomposition temperatureNot determined.
- Flash pointNot applicable.
- Explosion limitsLower: Not determined.
Upper: Not determined. - FlammabilityNot applicable.
- Boiling point/Boiling rangeUndetermined.
- Melting point/Melting rangeUndetermined.
- Odor ThresholdNot determined.
- Molecular Weight449.5 g/mol
- Structural FormulaC18H21NO3 C4H6O6
- OdorCharacteristic
- ColorWhite
- Physical StateLiquid
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
strong oxidizing agents
Hazardous decomposition products
carbon dioxide, carbon monoxide, nitrogen oxides
RTECS Number
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Route | Endpoint | Value |
|---|---|---|
| Oral | LD50 | 375 mg/kg (rat) |
| Subcutaneous | TDLO | 0.95 mg/kg (rat) |
| Intraperitoneal | TDLO | 2.76 mg/kg (rat) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
Sensitization possible through skin contact.
Additional toxicological information
Interactive effects
No interactive effects between components are known.
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Alternative sources for toxicological information
No non-standard sources for toxicological information where used.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
Additional ecological information
General notes
Water hazard class 1 (Self-assessment) slightly hazardous for water
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
UN-Number
DOT, IMDG, IATA UN2810
UN proper shipping name
DOT Toxic, liquids, organic, n.o.s. (Hydrocodone (bitartrate))
IMDG TOXIC LIQUID, ORGANIC, N.O.S. (Hydrocodone (bitartrate))
IATA Toxic liquid, organic, n.o.s. (Hydrocodone (bitartrate))
IMDG TOXIC LIQUID, ORGANIC, N.O.S. (Hydrocodone (bitartrate))
IATA Toxic liquid, organic, n.o.s. (Hydrocodone (bitartrate))
Transport hazard class(es)
DOTClass: 6.1 Toxic substances
Label: 6.1
IMDG, IATA
Label: 6.1
Class: 6.1 Toxic substances
Label: 6.1
Label: 6.1
Packing group
DOT, IMDG, IATA I
Environmental hazards
Not applicable.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 1 L
On cargo aircraft only: 30 L
On cargo aircraft only: 30 L
IMDG:
Limited quantities (LQ)
0
Excepted quantities (EQ)
Code: E5
Maximum net quantity per inner packaging: 1 ml
Maximum net quantity per outer packaging: 300 ml
Maximum net quantity per inner packaging: 1 ml
Maximum net quantity per outer packaging: 300 ml
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
Special precautions for user
Warning: Toxic substances
Hazard identification number (Kemler code)
66
EMS Number
F-A, S-A
Stowage Category
B
Stowage Code
SW2 Clear of living quarters.
UN "Model Regulation"
UN 2810 TOXIC LIQUID, ORGANIC, N.O.S.
(HYDROCODONE (BITARTRATE)), 6.1, I
(HYDROCODONE (BITARTRATE)), 6.1, I
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is not listed. |
| Section 313 (Specific toxic chemical listings): | Substance is not listed. |
| TSCA (Toxic Substances Control Act): | Substance is not listed. |
| Hazardous Air Pollutants: | Substance is not listed. |
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is not listed. |
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute toxicity - oral 1: Acute toxicity – Category 1
Acute toxicity - dermal 4: Acute toxicity – Category 4
Acute toxicity - inhalation 2: Acute toxicity – Category 2
Sensitization - respiratory 1B: Respiratory sensitisation – Category 1B
Sensitization - skin 1: Skin sensitisation – Category 1
Specific target organ toxicity (single exposure) 3: Specific target organ toxicity (single exposure) – Category 3
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute toxicity - oral 1: Acute toxicity – Category 1
Acute toxicity - dermal 4: Acute toxicity – Category 4
Acute toxicity - inhalation 2: Acute toxicity – Category 2
Sensitization - respiratory 1B: Respiratory sensitisation – Category 1B
Sensitization - skin 1: Skin sensitisation – Category 1
Specific target organ toxicity (single exposure) 3: Specific target organ toxicity (single exposure) – Category 3
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.