Chemical Safety Data Sheet MSDS / SDS

Isobutyronitrile

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Isobutyronitrile
CBnumber: CB9854381
CAS: 78-82-0
EINECS Number: 201-147-5
Synonyms: 2-METHYLPROPANENITRILE

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P240 Ground/bond container and receiving equipment.

P233 Keep container tightly closed.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

Hazard statements

H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

Product name: Isobutyronitrile
Synonyms: 2-METHYLPROPANENITRILE
CAS: 78-82-0
EC number: 201-147-5
MF: C4H7N
MW: 69.11

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately.
In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

4.4 Notes to physician

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Carbon oxides
Nitrogen oxides (NOx)
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	3	Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains. Risk of explosion.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Storage class

Storage class (TRGS 510): 3: Flammable liquids

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

8.2 Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

a) Physical stateliquid
b) ColorClear colorless to light yellow
c) Odorbitter almond-like
d) Melting point/freezing pointMelting point/range: -72 °C - lit.
e) Initial boiling point and boiling range107 - 108 °C - lit.
f) Flammability (solid, gas)No data available
g) Upper/lower flammability or explosive limitsUpper explosion limit: 12.7 %(V)
Lower explosion limit: 1.6 %(V)
h) Flash point8 °C - closed cup
i) Autoignition temperatureNo data available
j) Decomposition temperatureNo data available
k) pH6
l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: 0.35 mPa.s at 75 °C
m) Water solubility0.24 g/l at 25 °C
n) Partition coefficient n-octanol/waterlog Pow: 0.46 - (Lit.), Bioaccumulation is not expected.
o) Vapor pressure43.5 hPa at 25 °C 133 hPa at 54.4 °C
p) Density0.77 g/cm3 at 20 °C - lit.
Relative density0.770 g/mL at 20 °C (lit.)
q) Relative vapor density2.38 (vs air)
r) Particle characteristicsNo data available
s) Explosive propertiesNo data available
t) Oxidizing propertiesNo data available
Solubilityslightly soluble in water and acetone, very soluble in alcohol and ether
Dielectric constant23.9（Ambient）

9.2 Other safety information

Relative vapor density

2.4

SECTION 10: Stability and reactivity

10.1 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.2 Possibility of hazardous reactions

Violent reactions possible with:
Strong oxidizing agents
Strong acids strong alkalis strong reducing agents

10.3 Conditions to avoid

Warming.

10.4 Incompatible materials

various plastics

10.5 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 50 mg/kg
Remarks: (RTECS)
LC50 Inhalation - Rat - 4 h - 0.85 mg/l - vapor
Remarks: (External MSDS)
LD50 Dermal - Rabbit - 200 mg/kg
Remarks: (RTECS)

Skin corrosion/irritation