Chemical Safety Data Sheet MSDS / SDS

Isoflurane

Revision Date:2026-03-22Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Isoflurane
CBnumber: CB8437691
CAS: 26675-46-7
EINECS Number: 247-897-7
Synonyms: Forane

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordWarning

Precautionary statements

P501 Dispose of contents/container to..…

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P271 Use only outdoors or in a well-ventilated area.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

Hazard statements

H336 May cause drowsiness or dizziness

SECTION 3: Composition/information on ingredients

Substance

Product name: Isoflurane
Synonyms: Isoflurane,lsoflurane
CAS: 26675-46-7
EC number: 247-897-7
MF: C3H2ClF5O
MW: 184.49

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact

After eye contact: rinse out with plenty of water. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

4.4 Notes to physician

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Nature of decomposition products not known.
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.

5.3 Advice for firefighters

In the event of fire, wear self-contained breathing apparatus.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Hygiene measures

Change contaminated clothing. Wash hands after working with substance.
For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Keep locked up or in an area accessible only to qualified or authorized persons.

Storage class

Storage class (TRGS 510): 10: Combustible liquids

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis']	['(±)-Isoflurane', '26675-46-\n7', 'TWA', '50 ppm', 'USA. ACGIH Threshold Limit\nValues (TLV)']
['', '', 'PEL', '2 ppm15\nmg/m3', 'California permissible exposure\nlimits for chemical\ncontaminants (Title 8, Article\n107)']

Remarks Not classifiable as a human carcinogen

8.2 Exposure controls

Appropriate engineering controls

Change contaminated clothing. Wash hands after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

required

Body Protection

protective clothing

Respiratory protection

required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

a) Physical stateliquid
b) ColorColorless to Almost colorless
c) OdorNo data available
d) Melting point/freezing pointNo data available
e) Initial boiling point and boiling range48.5 °C
f) Flammability (solid, gas)No data available
g) Upper/lower flammability or explosive limitsNo data available
h) Flash point48-49°C
i) Autoignition temperatureNo data available
j) Decomposition temperatureNo data available
k) pHNo data available
l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available
m) Water solubilitySoluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
n) Partition coefficient n-octanol/waterNo data available
o) Vapor pressure238 mmHg ( 20 °C)
p) Density1.510 g/cm3 at 25 °C
Relative density1.510 g/mL at 25 °C
q) Relative vapor densityNo data available
r) Particle characteristicsNo data available
s) Explosive propertiesNo data available
t) Oxidizing propertiesnone
SolubilityPractically insoluble in water, miscible with ethanol and trichloroethylene.

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.2 Possibility of hazardous reactions

No data available

10.3 Conditions to avoid

no information available

10.4 Incompatible materials

Strong oxidizing agents

10.5 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 4,770 mg/kg
Remarks: (External MSDS)
LC50 Inhalation - Rat - 4 h - 11475 ppm - vapor
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Excitement.
Respiratory disorder
Dermal: No data available

Skin corrosion/irritation