11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - > 5.110 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: L-glutamic acid
Symptoms: Possible damages:, Nausea
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: L-glutamic acid
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)
Remarks: The value is given in analogy to the following substances: L-glutamic acid
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (Regulation (EC) No. 440/2008, Annex, B.5)
Remarks: The value is given in analogy to the following substances: L-glutamic acid
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Remarks: The value is given in analogy to the following substances: L-glutamic acid
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: L-glutamic acid
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Remarks: The value is given in analogy to the following substances: L-glutamic acid
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
This is a non-essential amino acid that occurs in many forms in natural protein.
Handle in accordance with good industrial hygiene and safety practice.