11.1 Information on toxicological effects
Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 500.1 mg/kg (Expert judgement)
Acute toxicity estimate Inhalation - 4 h - 1.5 mg/l - dust/mist (Expert judgement)
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage the unborn child. Positive evidence from human epidemiological stud- ies.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
May cause damage to organs through prolonged or repeated exposure.
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: OG4375000
Lead salts have been reported to cross the placenta and to induce embryo- and fe- to- mortality. They also have teratogenic effect in some animal species. No terato- genic effects have been reported with exposure to organometallic lead compounds.
Adverse effects of lead on human reproduction, embryonic and fetal development, and postnatal (e.g., mental) development have been reported. Excessive exposure can affect blood, nervous, and digestive systems. The synthesis of hemoglobin is inhibited and results in anemia. If left untreated, neuromuscular dysfunction, pos- sible paralysis, and encephalopathy can result. Additional symptoms of overexpo- sure include: joint and muscle pain, weakness of the extensor muscles (frequently the hand and wrist), headache, dizziness, abdominal pain, diarrhea, constipation, nausea, vomiting, blue line on the gums, insomnia, and metallic taste. High body levels produce increased cerebrospinal pressure, brain damage, and stupor leading to coma and often death.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.