11.1 Information on toxicological effects
Acute toxicity
Acute toxicity estimate Oral - 100.2 mg/kg (Calculation method)
Acute toxicity estimate Oral - 100.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: Nausea, Vomiting
Acute toxicity estimate Inhalation - 4 h - 3.1 mg/l - vapor(Calculation method)
Acute toxicity estimate Inhalation - 4 h - 3.1 mg/l - vapor (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: Irritation symptoms in the respiratory tract.
Acute toxicity estimate Dermal - 300.4 mg/kg (Calculation method)
Acute toxicity estimate Dermal - 300.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation
Remarks: (ECHA)
Remarks: Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
Remarks: (ECHA)
Respiratory or skin sensitization
Sensitisation test: - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Based on available data the classification criteria are not met.
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
Did not show carcinogenic effects in animal experiments.
Reproductive toxicity
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
Mixture causes damage to organs. - Eyes, Central nervous system
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Acute effects:, Headache, Dizziness, Drowsiness, narcosis, Blindness, Impairment of vision, irritant effects, Nausea, Vomiting, agitation, spasms, inebriation, Coma
Drying-out effect resulting in rough and chapped skin.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Systemic effects: acidosis drop in blood pressure agitation, spasms inebriation
Dizziness
Drowsiness
Headache
Impairment of vision
Blindness narcosis
Coma
Symptoms may be delayed.
Damage to:
Liver
Kidney
Cardiac
Irreversible damage of the optical nerve.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.