Chemical Safety Data Sheet MSDS / SDS
Periodic acid
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Periodic acid
- CBnumber: CB3405103
- CAS: 10450-60-9
- EINECS Number: 233-937-0
- Synonyms: H5IO6;PERIODIC ACID, DIHYDRATE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H410 Very toxic to aquatic life with long lasting effects
H372 Causes damage to organs through prolonged or repeated exposure
H314 Causes severe skin burns and eye damage
H271 May cause fire or explosion; strong oxidiser
Substance
- Product name: Periodic acid
- Synonyms: H5IO6;PERIODIC ACID, DIHYDRATE
- CAS: 10450-60-9
- EC number: 233-937-0
- MF: H5IO6
- MW: 227.941
General advice
First aiders need to protect themselves. Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Development of hazardous combustion gases or vapours possible in the event of fire. Has a fire-promoting effect due to release of oxygen.
Hazardous combustion products
Hydrogen iodide
Specific extinguishing methods
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
NFPA 704
3
0
1
OX
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. | OX |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition.
Avoidance of contact
Strong oxidizing agents
Storage
Further information on storage conditionsTightly closed. Keep locked up or in an area accessible only to qualified or authorised persons. Separately or together with other oxidising substances only and away from sources of ignition and heat.Because of their oxidation potential these products can raise the burning rate of combustible substances substantially or ignite combustible substances on contact with them.
Storage class
5.1A, Strongly oxidizing hazardous materials
Recommended storage temperature
Recommended storage temperature see product label.
Further information on storage stability
Light sensitive. hygroscopic
control parameter
Hazard composition and occupational exposure limitsDoes not contain substances with occupational exposure limits.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type P2
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Tightly fitting safety goggles
protective clothing
Hand protection
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Full contact
Manufacturer
KCL 741 L
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Splash contact
Manufacturer
KCL 741 L
Remarks
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D- 36124 Eichenzell, Internet: www.kcl.de).
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Physical stateSolid
- Solubility in other solventssoluble
Ethanol: (20 °C) - Particle characteristics Particle sizeNo data available
- Molecular weight227.94 g/mol
- Oxidizing propertiesThe substance or mixture is classified as oxidizing with the category 1.
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperature130 - 140 °C
- Autoignition temperatureNo data available
- Partition coefficient: n-octanol/waterNot applicable for inorganic substances
- Water solubility8 g/l soluble (20 °C)
- Density3.37 g/cm3 (20 °C)
Method: OECD Test Guideline 109
GLP: yes - Relative densityd417 1.3875; d 1.42
- Relative vapor density3.37 (20 °C )
- Vapor pressure< 0.076 hPa (20 °C)
Method: OECD Test Guideline 104
GLP: yes - Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Self-ignition262 °C
Method: Regulation (EC) No. 440/2008, Annex, A.16
GLP: yes - Burning rateNo data available
- Evaporation rateNo data available
- Flash point140°C
- Boiling point/boiling range140°C
- Melting point/ range122 °C
Method: lit. - pH> 3 - < 4.9
Method: OECD Test Guideline 105
GLP: yes - pH1.2 (100g/l, H2O, 20℃)
- Odor ThresholdNot applicable
- Odorodourless
- Colorcolourless
- Appearancesolid (20 °C , 1,013 hPa)
Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Risk of explosion with: dimethyl sulfoxide oxidisable substances Exothermic reaction with: phosphorus Violent reactions possible with: organic combustible substances nonmetals
Conditions to avoid
hygroscopic no information available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityOral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Skin - Human
Result: Skin irritation - 1 h (OECD Test Guideline 431)
Serious eye damage/eye irritation
Result: Skin irritation - 1 h (OECD Test Guideline 431)
Eyes - In vitro study
Result: Eye irritation (OECD Test Guideline 437)
Respiratory or skin sensitization
Result: Eye irritation (OECD Test Guideline 437)
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Carcinogenicity
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Ingestion - Causes damage to organs through prolonged or repeated exposure.
- Thyroid
Aspiration hazard
- Thyroid
Classified based on available data. For more details, see section 2
11.2 Additional Information
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea,
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Ecotoxicity
Components:
Periodic acid:
Toxicity to fishLC50 (Oncorhynchus mykiss (rainbow trout)): < 0.17 mg/l End point: mortality Exposure time: 96 h Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 203 GLP: yes
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 0.18 mg/l End point: Immobilization Exposure time: 48 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 202 GLP: yes
Toxicity to algae/aquatic plants
EC50 (Pseudokirchneriella subcapitata): 2.5 mg/l Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes
M-Factor (Chronic aquatic toxicity)
1
Toxicity to microorganisms
EC50 (activated sludge): 220 mg/l Exposure time: 3 h Test Type: Respiration inhibition Method: OECD Test Guideline 209 GLP: yes NOEC (activated sludge): 56 mg/l Exposure time: 3 h Test Type: Respiration inhibition Method: OECD Test Guideline 209 GLP: yes
Ecotoxicology Assessment
Acute aquatic toxicityVery toxic to aquatic life.
Persistence and degradability
Components:
Periodic acid:
BiodegradabilityRemarks: The methods for determining the biological degradability are not applicable to inorganic substances.
Bioaccumulative potential
Components:
Periodic acid:
Partition coefficient: noctanol/waterRemarks: Not applicable for inorganic substances
Mobility in soil
No data available
Other adverse effects
No data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 3085
Proper shipping name : Oxidizing solid, corrosive, n.o.s.
(Periodic acid)
Class : 5.1
Subsidiary risk : 8
Packing group : I
Labels : Division 5.1 - Oxidizing substances, Class 8 - Corrosive substances
Packing instruction (cargo aircraft) : 561
Packing instruction (passenger aircraft) : 557
Proper shipping name : Oxidizing solid, corrosive, n.o.s.
(Periodic acid)
Class : 5.1
Subsidiary risk : 8
Packing group : I
Labels : Division 5.1 - Oxidizing substances, Class 8 - Corrosive substances
Packing instruction (cargo aircraft) : 561
Packing instruction (passenger aircraft) : 557
IMDG-Code
UN number : UN 3085
Proper shipping name : OXIDIZING SOLID, CORROSIVE, N.O.S.
(Periodic acid)
Class : 5.1
Subsidiary risk : 8
Packing group : I
Labels : 5.1 (8)
EmS Code : F-A, S-Q
Marine pollutant : yes
Proper shipping name : OXIDIZING SOLID, CORROSIVE, N.O.S.
(Periodic acid)
Class : 5.1
Subsidiary risk : 8
Packing group : I
Labels : 5.1 (8)
EmS Code : F-A, S-Q
Marine pollutant : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : UN 3085
Proper shipping name : OXIDIZING SOLID, CORROSIVE, N.O.S.
(Periodic acid)
Class : 5.1
Subsidiary risk : 8
Packing group : I
Labels : 5.1 (8)
Environmentally hazardous : no
Proper shipping name : OXIDIZING SOLID, CORROSIVE, N.O.S.
(Periodic acid)
Class : 5.1
Subsidiary risk : 8
Packing group : I
Labels : 5.1 (8)
Environmentally hazardous : no
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
No. / Code Chemical name / Category Threshold quantity
W9.2 Oxidising solids and liquids 200 t
Hazardous Chemicals for Priority Management
Not listed under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Not listed
Regulations on Labour Protection in Workplaces where Toxic Substances are Used
Catalogue of Highly Toxic Chemicals
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not listed
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
ACGIH / TWA AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardisation; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; MERC of Dangerous Goods; n.o. - No Observed (Adverse) fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organisatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
8-hour, time-weighted average ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.