Chemical Safety Data Sheet MSDS / SDS
Phenylmagnesium bromide
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Phenylmagnesium bromide
- CBnumber: CB1153390
- CAS: 100-58-3
- EINECS Number: 202-867-2
- Synonyms: PhMgBr;bromophenylmagnesium
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H314 Causes severe skin burns and eye damage
H302 Harmful if swallowed
H225 Highly Flammable liquid and vapour
Substance
- Product name: Phenylmagnesium bromide
- Synonyms: PhMgBr;bromophenylmagnesium
- CAS: 100-58-3
- EC number: 202-867-2
- MF: C6H5BrMg
- MW: 181.31
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaCarbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
Water Foam
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Hydrogen bromide gas
Magnesium oxide
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
Hydrogen bromide gas
Magnesium oxide
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
3
2
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingKeep workplace dry. Do not allow product to come into contact with water.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.
Never allow product to get in contact with water during storage.
Handle and store under inert gas. Air and moisture sensitive. Test for peroxide formation periodically and before distillation. Test for peroxide formation periodically and before distillation.
Storage class
Never allow product to get in contact with water during storage.
Handle and store under inert gas. Air and moisture sensitive. Test for peroxide formation periodically and before distillation. Test for peroxide formation periodically and before distillation.
Storage class (TRGS 510): 3: Flammable liquids
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0.3 mm
Break through time: 10 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0.3 mm
Break through time: 10 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorYellow to brown
- c) OdorNo data available
- d) Melting point/freezing pointNo data available
- e) Initial boiling point and boiling rangeNo data available
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point-11 °C
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityreacts
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.1612 g/cm3 at 25 °C
- Relative density1.134 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNot classified as explosive.
- t) Oxidizing propertiesnone
- SolubilityMiscible with tetrahydrofuran.
- AppearanceClear to slightly hazy colorless to dark brown liquid.
9.2 Other safety information
No data available
10.1 Chemical stability
sensitive to moisture
10.2 Possibility of hazardous reactions
No data available
10.3 Conditions to avoid
Warming.
Moisture.
Moisture.
10.4 Incompatible materials
Water, Strong bases, Strong oxidizing agents, Strong acids, Alcohols, acids
10.5 Hazardous decomposition products
Peroxides
In the event of fire: see section 5
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityAcute toxicity estimate Oral - 943.4 mg/kg (Calculation method)
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Risk of blindness!
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components 2-Methyltetrahydrofuran
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - female - > 300 - 2,000 mg/kg (OECD Test Guideline 420)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - In vitro study
Result: irritating - 15 min (OECD Test Guideline 439)
Result: irritating - 15 min (OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Corrosive - 10 min (OECD Test Guideline 437)
Result: Corrosive - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 429)
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Carcinogenicity
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Acute oral toxicity - Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Acute inhalation toxicity - Possible damages:, mucosal irritations
Classified based on available data. For more details, see section 2
Bromophenylmagnesium Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
12.1 Toxicity
MixtureNo data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
Components 2-Methyltetrahydrofuran
Toxicity to fish semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - > 100 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - > 139 and other aquatic mg/l - 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 104 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - >= 120 and other aquatic mg/l - 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
Bromophenylmagnesium
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - > 139 and other aquatic mg/l - 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 104 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - >= 120 and other aquatic mg/l - 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 2924
IMDG: 2924
IATA-DGR: 2924
IMDG: 2924
IATA-DGR: 2924
14.2 UN proper shipping name
ADR/RID: FLAMMABLE LIQUID, CORROSIVE, N.O.S. (2-Methyltetrahydrofuran,
Bromophenylmagnesium) (2-Methyltetrahydrofuran,
Bromophenylmagnesium)
IMDG: FLAMMABLE LIQUID, CORROSIVE, N.O.S. (2-Methyltetrahydrofuran,
Bromophenylmagnesium) (2-Methyltetrahydrofuran,
Bromophenylmagnesium)
IATA-DGR: Flammable liquid, corrosive, n.o.s. (2-Methyltetrahydrofuran,
Bromophenylmagnesium) (2-Methyltetrahydrofuran,
Bromophenylmagnesium)
Bromophenylmagnesium) (2-Methyltetrahydrofuran,
Bromophenylmagnesium)
IMDG: FLAMMABLE LIQUID, CORROSIVE, N.O.S. (2-Methyltetrahydrofuran,
Bromophenylmagnesium) (2-Methyltetrahydrofuran,
Bromophenylmagnesium)
IATA-DGR: Flammable liquid, corrosive, n.o.s. (2-Methyltetrahydrofuran,
Bromophenylmagnesium) (2-Methyltetrahydrofuran,
Bromophenylmagnesium)
14.3 Transport hazard class(es)
ADR/RID: 3 (8)
IMDG: 3 (8)
IATA-DGR: 3 (8)
IMDG: 3 (8)
IATA-DGR: 3 (8)
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
Water, Strong bases, Strong oxidizing agents, Strong acids, Alcohols, acids
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222221994
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222221994
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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