Chemical Safety Data Sheet MSDS / SDS
Pinacolone
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Pinacolone
- CBnumber: CB5245383
- CAS: 75-97-8
- EINECS Number: 200-920-4
- Synonyms: 3,3-DIMETHYLBUTAN-2-ONE;3,3-DIMETHYL-2-BUTANONE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H302 Harmful if swallowed
H225 Highly Flammable liquid and vapour
Substance
- Product name: Pinacolone
- Synonyms: 3,3-DIMETHYLBUTAN-2-ONE;3,3-DIMETHYL-2-BUTANONE
- CAS: 75-97-8
- EC number: 200-920-4
- MF: C6H12O
- MW: 100.16
Eye Contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.
Skin Contact
Wash off immediately with plenty of water for at least 15 minutes. Get medical attention.
Inhalation
Remove to fresh air. Get medical attention. If not breathing, give artificial respiration.
Ingestion
Do NOT induce vomiting. Get medical attention.
Most important symptoms and effects
Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Self-Protection of the First Aider
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Water spray. Carbon dioxide (CO2). Dry chemical. Alcohol resistant foam. Water mist may be used to cool closed containers.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA 704
2
3
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
desc_info
| Personal Precau | tions | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ensure adequate | ventilation. | Use personal | p | rot | ective | equipment | as | required. | Avoid | con | tact | with s | kin, eyes or | clothin | g. | Remove | all |
| sources of ignition | . Take prec | autionary me | a | sur | es aga | inst static d | isc | harges. | |||||||||
| Environmental P | recautions | ||||||||||||||||
| See Section 12 fo | r additional | Ecological Inf | o | rm | ation. | Do not flush | int | o surface | water | or | sanit | ary se | wer system. | ||||
| Methods for Con | tainment a | nd Clean Up | |||||||||||||||
| Soak up with inert | absorbent | material (e.g. | s | an | d, silic | a gel, acid b | ind | er, univer | sal bin | de | r, sa | wdust) | . Keep in su | itable, | cl | osed | |
| containers for dis | posal. Rem | ove all source | s | of i | gnition | . Use spar | k-p | roof tools | and ex | plo | sion | -proof | equipment. | ||||
| Refer to protective | measures | listed in Secti | o | ns | 8 and | 13. |
Handling
Ensure adequate ventilation. Wear personal protective equipment/face protection. Use spark-proof tools and explosion-proof equipment. Use only non-sparking tools. Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapors). Keep away from open flames, hot surfaces and sources of ignition. Avoid contact with skin, eyes or clothing. Avoid breathing dust/fume/gas/mist/vapors/spray. Take precautionary measures against static discharges. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.
Storage
Flammables area. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed in a dry and well-ventilated place. Keep away from heat, sparks and flame.
Specific Use(s)
Use in laboratories
Control Parameters
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS70 General methods for sampling airborne gases and vapours MDHS 88
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Exposure Controls
Engineering Measures
Ensure adequate ventilation, especially in confined areas. Use explosion-proof electrical/ventilating/lighting equipment. Ensure that eyewash stations and safety showers are close to the workstation location. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionWear safety glasses with side shields (or goggles) (European standard - EN 166)
Hand Protection
Protective gloves
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Nitrile rubber | See manufacturers | - | EN 374 | (minimum requirement) |
| Neoprene | recommendations | |||
| Natural rubber | ||||
| PVC |
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Wear appropriate protective gloves and clothing to prevent skin exposure
Respiratory Protection
No protective equipment is needed under normal use conditions.
Large scale/emergency use
Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
Small scale/Laboratory use
Maintain adequate ventilation
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
Prevent product from entering drains.
Information on basic physicochemical properties
- Dielectric constant12.8（17℃）
- ColourClear colorless to light yellow
- Molecular Weight100.16
- Molecular FormulaC6 H12 O
- Oxidizing PropertiesNo information available
- Explosive PropertiesVapors may form explosive mixtures with air
- ViscosityNo data available
- Decomposition TemperatureNo data available
- Autoignition TemperatureNo data available
- desc_infoComponent: Pinacolone log Pow: 1.27
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solvents19g/l
- Water SolubilityVery soluble
- Bulk DensityNot applicable Liquid
- Specific Gravity / Density0.800
- Vapor Density3.45 (Air = 1.0 ) (Air = 1.0)
- Vapor Pressure31.5 mmHg @ 25 °C
- Explosion LimitsNo data available
- Flammability (solid,gas)Not applicable Liquid
- Evaporation RateNo data available
- Flash Point5 °C / 41 °F Method - No information available
- Boiling Point/Range106 - °C / 222.8 - 194 °F @ 760 mmHg
- Softening PointNo data available
- Melting Point/Range52.5 °C / -62.5 °F
- pHNo information available
- Odor ThresholdNo data available
- Odorethereal-minty-camphoraceous,warm-sweet odor
- Physical StateLiquid
- AppearanceClear
Stability
No information available.
Hazardous Reactions
No information available.
Hazardous Polymerization
No information available.
Conditions to Avoid
Keep away from open flames, hot surfaces and sources of ignition. Incompatible products.
Materials to avoid
Strong oxidizing agents.
Hazardous Decomposition Products
Carbon monoxide (CO). Carbon dioxide (CO2).
Product Information
(a) acute toxicity;
| Component | LD50 Oral | LD50 Dermal | LC50 Inhalation |
|---|---|---|---|
| Pinacolone | LD50 = 610 mg/kg ( Rat ) |
(b) skin corrosion/irritation;
No data available
(c) serious eye damage/irritation;
No data available
(d) respiratory or skin sensitization;
RespiratoryNo data available
Skin
No data available
(e) germ cell mutagenicity;
No data available
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
(h) STOT-single exposure;
No data available
(i) STOT-repeated exposure;
No data available
Target Organs
No information available.
(j) aspiration hazard;
No data available
Other Adverse Effects
The toxicological properties have not been fully investigated.
Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, delayed
tiredness, nausea and vomiting
Ecotoxicity effects
Harmful to aquatic organisms. Do not empty into drains. Do not flush into surface water or sanitary sewer system. Do not allow material to contaminate ground water system.
Contains a substance which is: . The product contains following substances which are hazardous for the environment.
Contains a substance which is: . The product contains following substances which are hazardous for the environment.
| Component | Freshwater Fish | Water Flea | Freshwater Algae | Microtox |
|---|---|---|---|---|
| Pinacolone | LC50: = 87 mg/L, 96h flow-through (Pimephales promelas) |
Persistence and Degradability
Persistence
Soluble in water, Persistence is unlikely, based on information available.
Degradation in sewage
Contains substances known to be hazardous to the environment or not degradable in waste
treatment plant
water treatment plants.
Bioaccumulative Potential
Bioaccumulation is unlikely
| Component | log Pow | Bioconcentration factor (BCF) |
|---|---|---|
| Pinacolone | 1.27 | No data available |
Mobility in soil
The product is water soluble, and may spread in water systems Will likely be mobile in the environment due to its water solubility Highly mobile in soils
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging
Dispose of this container to hazardous or special waste collection point. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep product and empty container away from heat and sources of ignition.
Other Information
Do not flush to sewer. Waste codes should be assigned by the user based on the application for which the product was used. Can be landfilled or incinerated, when in compliance with local regulations.
Road and Rail Transport
UN-NoUN1224
Proper Shipping Name
KETONES, LIQUID, N.O
Technical Shipping Name
3,3-Dimethyl-2-butanone
Hazard Class
3
Packing Group
II
IMDG/IMO
UN-NoUN1224
Proper Shipping Name
KETONES, LIQUID, N.O
Technical Shipping Name
3,3-Dimethyl-2-butanone
Hazard Class
3
Packing Group
II
IATA
UN-NoUN1224
Proper Shipping Name
KETONES, LIQUID, N.O
Technical Shipping Name
3,3-Dimethyl-2-butanone
Hazard Class
3
Packing Group
II
Special Precautions for User
No special precautions r
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pinacolone | X | X | X | X | 200-920-4 | X | X | X | X | X | X | KE-11259 |
National Regulations
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.