Chemical Safety Data Sheet MSDS / SDS
Pregabalin
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Pregabalin
- CBnumber: CB2251105
- CAS: 148553-50-8
- EINECS Number: 604-639-1
- Synonyms: Pregablin;Prebagalin
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
Hazard statements
H336 May cause drowsiness or dizziness
H361 Suspected of damaging fertility or the unborn child
Substance
- Product name: Pregabalin
- Synonyms: pregabalin,pregablin
- CAS: 148553-50-8
- EC number: 604-639-1
- MF: C8H17NO2
- MW: 159.23
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Nature of decomposition products not known.
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
0
3
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact.
Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Dry.
Storage stability
Recommended storage temperature 2 - 8 °C
Storage class
Storage class (TRGS 510): 11: Combustible Solids
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsChange contaminated clothing. Wash hands after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
Handle with gloves.
Body Protection
protective clothing
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full- face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical statesolid
- b) Coloroff-white, white
- c) OdorNo data available
- d) Melting point/freezing pointMelting point: 195 °C - (solvent)
- e) Initial boiling point and boiling range274.0±23.0 °C(Predicted)
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point9℃
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilitySoluble to 100 mM in water
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density0.997±0.06 g/cm3(Predicted)
- Relative density0.997±0.06 g/cm3(Predicted)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- Solubilitydeionized water: ≥10mg/mL
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Stable under recommended storage conditions.
Stable under recommended storage conditions.
10.2 Possibility of hazardous reactions
No data available
10.3 Conditions to avoid
no information available
10.4 Incompatible materials
Strong oxidizing agents
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - > 5,000 mg/kg
Remarks: (External MSDS)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: (External MSDS)
Inhalation: No data available
Dermal: No data available
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative
Remarks: (External MSDS)
Germ cell mutagenicity
Result: negative
Remarks: (External MSDS)
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (External MSDS)
Test Type: unscheduled DNA synthesis assay
Species: Rat
Result: negative
Remarks: (External MSDS)
Carcinogenicity
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (External MSDS)
Test Type: unscheduled DNA synthesis assay
Species: Rat
Result: negative
Remarks: (External MSDS)
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Suspected of damaging fertility.
May cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12.1 Toxicity
Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - > 1,000 mg/l - 96 h
Remarks: (External MSDS)
Toxicity to daphnia EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h and other aquatic Remarks: (External MSDS) invertebrates
Toxicity to algae EbC50 - Scenedesmus quadricauda (Green algae) - > 300 mg/l - 72 h
Remarks: (External MSDS)
ErC50 - Scenedesmus quadricauda (Green algae) - > 300 mg/l - 72 h
Remarks: (External MSDS)
Remarks: (External MSDS)
Toxicity to daphnia EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h and other aquatic Remarks: (External MSDS) invertebrates
Toxicity to algae EbC50 - Scenedesmus quadricauda (Green algae) - > 300 mg/l - 72 h
Remarks: (External MSDS)
ErC50 - Scenedesmus quadricauda (Green algae) - > 300 mg/l - 72 h
Remarks: (External MSDS)
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
14.7 Incompatible materials
Strong oxidizing agents
Further information: Not classified as dangerous in the meaning of transport regulations.
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222212760
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222212760
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.