Chemical Safety Data Sheet MSDS / SDS
Propionitrile
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Propionitrile
- CBnumber: CB9852701
- CAS: 107-12-0
- EINECS Number: 203-464-4
- Synonyms: PROPIONONITRILE;Propanenitrile
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
Hazard statements
H225 Highly Flammable liquid and vapour
H300 Fatal if swallowed
H310 Fatal in contact with skin
H319 Causes serious eye irritation
H331 Toxic if inhaled
Substance
- Product name: Propionitrile
- Synonyms: PROPIONONITRILE;Propanenitrile
- CAS: 107-12-0
- EC number: 203-464-4
- MF: C3H5N
- MW: 55.08
First Aid Measures
General adviceConsult a physician if necessary. Remove to fresh air.
Eye contact
Wash with plenty of water.
Skin Contact
Wash skin with soap and water.
Inhalation
Remove to fresh air If breathing is difficult, give oxygen If not breathing, give artificial respiration
Ingestion
Never give anything by mouth to an unconscious person. Clean mouth with water.
Most important symptoms and effects, both acute and delayed
SymptomsNo information available.
Indication of any immediate medical attention and special treatment needed
Note to physiciansTreat symptomatically.
Suitable Extinguishing Media
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
No information available.
Specific hazards arising from the chemical
Specific hazards arising from the chemicalflammable.
Hazardous combustion products
Carbon oxides. Hydrogen cyanide. Nitrogen oxides (NOx).
Explosion data
Sensitivity to Mechanical ImpactNo information available.
Sensitivity to Static Discharge
No information available.
Protective equipment and precautions for firefighters
Protective equipment and precautions for firefightersAs in any fire, wear self contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA 704
4
3
1
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal precautionsRemove all sources of ignition. Use personal protective equipment as required.
Environmental precautions
Environmental precautionsSee Section 12 for additional Ecological Information. Do not flush into surface water or sanitary sewer system.
Methods and material for containment and cleaning up
Methods for containmentPrevent further leakage or spillage if safe to do so.
Methods for cleaning up
Soak up with inert absorbent material.
Precautions for safe handling
Advice on safe handlingHandle in accordance with good industrial hygiene and safety practice.
Conditions for safe storage, including any incompatibilities
Storage ConditionsKeep away from heat, sparks, flame and other sources of ignition (i.e., pilot lights, electric motors and static electricity). Store at room temperature.
Incompatible materials
None known based on information supplied.
Control parameters
Exposure Guidelines.
Other Information
Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d 962 (11th Cir., 1992).
| Column 1 | Column 2 | Column 3 | Column 4 |
|---|---|---|---|
| Propionitrile 107-12-0 | - | TWA: 5 mg/m3 CN (vacated) TWA: 5 mg/m3 S* as CN | IDLH: 25 mg/m3 CN TWA: 6 ppm TWA: 14 mg/m3 |
Appropriate engineering controls
Engineering ControlsShowers
Eyewash stations
Ventilation systems
Eyewash stations
Ventilation systems
Individual protection measures, such as personal protective equipment
Eye/face protectionWear safety glasses with side shields (or goggles).
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
Handle in accordance with good industrial hygiene and safety practice.
Information on basic physicochemical properties
- Physical Stateliquid
- AppearanceNo information available
- OdorNo information available
- pH10 (20°C, 50g/L in H2O)
- Melting point/freezing point-93 °C
- Boiling point97 °C
- Flash point6 °C CC (closed cup)
- Liquid Density0.77 g/mL
- Evaporation rateNo information available
- Upper flammability limitsNo information available
- Lower flammability limitNo information available
- Vapor pressure53.33-63.195hPa at 22.05-25℃
- Vapor densityNo information available
- Specific gravityNo information available
- Water solubilitydecomposes. 5-10 g/100 mL at 23 ºC
- Solubility in other solventsNo information available
- Partition coefficientNo information available
- Autoignition temperatureNo information available
- Decomposition temperatureNo information available
- Kinematic viscosityNo information available
- Explosive propertiesNo information available
- Oxidizing propertiesNo information available
- Density and/or relative density0.772 g/mL at 25 °C (lit.)
- Solubilitysoluble in water at 40°C is 11.9 g/100 g H20; miscible with alcohol, ether, dimethylformamide
- ColourClear Colourless
- Upper/lower flammability or explosive limits3.1-14% (v/v)
- Dielectric constant27.7（20℃）
Reactivity
Not applicable
Chemical stability
Stable under recommended storage conditions.
Possibility of Hazardous Reactions
Contact with acids may liberate toxic gas.
Hazardous polymerization
No information available.
Conditions to avoid
Extremes of temperature and direct sunlight.
Incompatible materials
Strong oxidizing agents.
Hazardous Decomposition Products
Carbon oxides. Hydrogen cyanide. Nitrogen oxides (NOx).
Information on likely routes of exposure
InhalationClassified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.
Information on toxicological effects
SymptomsClassified based on available data. For more details, see section 2.
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Chronic ToxicityMay cause adverse liver effects. Target Organ Effects Central Vascular System (CVS), Central nervous system, Eyes, Respiratory system, Kidney, Liver, Skin.
Numerical measures of toxicity - Product Information
Unknown acute toxicityClassified based on available data. For more details, see section 2
The following values are calculated based on chapter 3.1 of the GHS document
ATEmix (oral)
The following values are calculated based on chapter 3.1 of the GHS document
39 mg/kg
ATEmix (dermal)
50 mg/kg
ATEmix (inhalation-dust/mist)
3.3 mg/l
Ecotoxicity
| Chemical name | Algae/aquatic plants | Fish | Toxicity to Microorganisms | Crustacea |
|---|---|---|---|---|
| Propionitrile 107-12-0 | - | 1450 - 1580: 96 h Pimephales promelas mg/L LC50 flow-through | - | - |
Propionitrile - 1450 - 1580: 96 h
- -
107
12-0 Pimephales promelas mg/L
LC50 flow
through
0% of the mixture consists of components(s) of unknown hazards to the aquatic environment.
0% of the mixture consists of components(s) of unknown hazards to the aquatic environment.
Persistence and degradability No information available. Bioaccumulation No information available. Mobility No information available.
Propionitrile
0.16
107-12-0
-0.10
Disposal of wastes
Disposal should be in accordance with applicable regional, national and local laws and regulations.
Contaminated packaging
Do not reuse container.
US EPA Waste Number
D001
DOT
UN/ID noUN2404
Hazard Class
3
Subsidiary class
6.1
Packing Group
II
Propionitrile
Reportable Quantity (RQ) (Propionitrile: RQ (kg)= 4.54)
UN2404, Propionitrile, 3 (6.1), II, Marine pollutant
Marine pollutant This product contains a chemical which is listed as a marine pollutant according to DOT
Emergency Response Guide Number
Propionitrile
Reportable Quantity (RQ) (Propionitrile: RQ (kg)= 4.54)
UN2404, Propionitrile, 3 (6.1), II, Marine pollutant
Marine pollutant This product contains a chemical which is listed as a marine pollutant according to DOT
131
IMDG
UN/ID noUN2404
Hazard Class
3
Subsidiary hazard class
6.1
Packing Group
II
Propionitrile
UN2404, Propionitrile, 3 (6.1), II, (6°C c.c.)
EmS-No
Propionitrile
UN2404, Propionitrile, 3 (6.1), II, (6°C c.c.)
F-E, S-D
IATA
UN/ID noUN2404
Hazard Class
3
Subsidiary hazard class
6.1
Packing Group
II
Propionitrile
UN2404, Propionitrile, 3 (6.1), II
ERG Code
Propionitrile
UN2404, Propionitrile, 3 (6.1), II
3P
International Inventories
All of the components in the product are on the following Inventory lists
TSCA (United States): Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP) Australia (AICS) China (IECSC) ENCS (Japan):
X - Listed
Philippines (PICCS)
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
TSCA (United States): Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP) Australia (AICS) China (IECSC) ENCS (Japan):
X - Listed
Philippines (PICCS)
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
| Chemical name | TSCA | DSL | NDSL | EINECS | ELINCS | ENCS | IECSC | KECL | PICCS | AICS |
|---|---|---|---|---|---|---|---|---|---|---|
| Propionitrile | X | X | - | X | - | X | X | - | X | X |
US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
SARA 311/312 Hazard Categories
Acute health hazardYes
Chronic Health Hazard
No
Fire hazard
Yes
Sudden release of pressure hazard
No
Reactive hazard
No
CWA (Clean Water Act)
This product contains the following substances which are regulated pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42).
| Chemical name | CWA - Reportable Quantities | CWA - Toxic Pollutants | CWA - Priority Pollutants | CWA - Hazardous Substances |
|---|---|---|---|---|
| Propionitrile 107-12-0 | X | X |
US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
| Chemical name | New Jersey | Massachusetts | Pennsylvania |
|---|---|---|---|
| Propionitrile 107-12-0 | X | X | X |
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.