11.1 Information on toxicological effects
Acute toxicity
Acute toxicity estimate Oral - 500.1 mg/kg (Expert judgement)
Acute toxicity estimate Inhalation - 4 h - 1.6 mg/l - dust/mist (Expert judgement)
Acute toxicity estimate Dermal - 1,100.1 mg/kg (Expert judgement)
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Inorganic tin salts are poorly absorbed into the body. When parenterally adminis- tered tin salts are highly toxic. Tin oxide inhaled as a dust or fume leads to a be- nign pneumoconiosis with no sign of interference with pulmonary function. Depos- ited dust appears nodular with the particles being mostly extracelluar. No necrosis, foreign-body giant-cell reaction, or collagen formation has been seen. Tin salts that have gained access to the blood stream are highly toxic and produce neurologic damage and paralysis. With most common tin salts, the toxicity profile is compli- cated by hydrolysis in body fluids producing unphysiologic pH values. The reported symptoms of hyperemia, vascular changes with bleeding in the central nervous system, liver, heart, and other organs may be due to tin itself or to the unphysio- logical pH changes. Ingestion produces vomiting due to the gastric irritation from the activity and astringency of tin compounds. Injection of inorganic tin salts pro- duces diarrhea, muscle paralysis, and twitching., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investi- gated.