11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Inhalation - 4 h - 11,01 mg/l - vapor(Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Acute toxicity estimate Dermal - 1.502 mg/kg (Calculation method)
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Treat as cyanide poisoning., Always have on hand a cyanide first-aid kit, together with proper instructions., The onset of symptoms is generally delayed pending conversion to cyanide., Nausea, Vomiting, Diarrhea, Headache, Dizziness, Rash, Cyanosis
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components Acetonitrile
Acute toxicity
LD50 Oral - Mouse - male and female - 617 mg/kg (OECD Test Guideline 401)
Acute toxicity estimate Oral - 617 mg/kg (ATE value derived from LD50/LC50 value)
LC50 Inhalation - Mouse - male and female - 4 h - 6,022 mg/l - vapor (OECD Test Guideline 403)
Acute toxicity estimate Dermal - 1.500 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye irritation.
(OECD Test Guideline 405)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: Positive results were obtained in some in vitro tests.
Remarks: (National Toxicology Program)
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Result: negative
Remarks: Sister chromatid exchange
Test system: Saccharomyces cerevisiae
Result: positive
Remarks: Cytogenetic analysis (ECHA)
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female
Result: negative
Carcinogenicity
No evidence of carcinogenicity in animal studies.
Reproductive toxicity
Animal testing did not show any effects on fertility.
Specific target organ toxicity - single exposure
The substance or mixture is not classified as specific target organ toxicant, single exposure.
Specific target organ toxicity - repeated exposure
The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration hazard
No aspiration toxicity classification
Testosterone Acute toxicity
LD50 Oral - Rat - male - 500 - 1.000 mg/kg (OECD Test Guideline 423)
The value is given in analogy to the following substances: 4-Androstene-3,17-dione
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402)
The value is given in analogy to the following substances: 4-Androstene-3,17-dione
Skin corrosion/irritation
Skin - Rat
Result: No skin irritation - 24 h
Remarks: (ECHA) (in analogy to similar products)
The value is given in analogy to the following substances: 4-Androstene-3,17-dione
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: 4-Androstene-3,17-dione
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: 4-Androstene-3,17-dione
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Suspected of causing cancer.
Reproductive toxicity
May damage the unborn child.
May damage fertility.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2