Chemical Safety Data Sheet MSDS / SDS
Vitamin E
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Vitamin E
- CBnumber: CB7132531
- CAS: 59-02-9
- EINECS Number: 200-412-2
- Synonyms: D-ALPHA-TOCOPHEROL;α-Tocopherol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Substance
- Product name: Vitamin E
- Synonyms: α-tocopherol,Vitamin E oil
- CAS: 59-02-9
- EC number: 200-412-2
- MF: C29H50O2
- MW: 430.71
4.1 Description of first-aid measures
If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
5.1 Extinguishing media
Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
NFPA 704
0
1
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Avoid breathing vapors, mist or gas.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
No special environmental precautions required.
6.3 Methods and materials for containment and cleaning up
Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsStore in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage stability
Recommended storage temperature -20 °C
Air and light sensitive. Store under inert gas. Hygroscopic.
Storage class
Air and light sensitive. Store under inert gas. Hygroscopic.
Storage class (TRGS 510): 10: Combustible liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
8.1 Control parameters
Ingredients with workplace control parameters8.2 Exposure controls
Personal protective equipmentEye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Body Protection
Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
No special environmental precautions required.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) Colorclear yellow
- c) Odorlt. yel. to red visc. oil, nearly odorless
- d) Melting point/freezing pointNo data available
- e) Initial boiling point and boiling range200 - 220 °C at 0,13 hPa
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point110 °C
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityINSOLUBLE
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density0.95 g/mL at 25 °C(lit.)
- Relative density0.95 g/mL at 25 °C(lit.)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesNo data available
- SolubilityPractically insoluble in water, freely soluble in acetone, in anhydrous ethanol, in methylene chloride and in fatty oils.
9.2 Other safety information
No data available
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male and female - >= 7.500 mg/kg (OECD Test Guideline 401)
Remarks: The value is given in analogy to the following substances: Tocopherol
Inhalation: No data available
LD50 Dermal - Rabbit - male and female - > 5.000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Skin corrosion/irritation
Remarks: The value is given in analogy to the following substances: Tocopherol
Inhalation: No data available
LD50 Dermal - Rabbit - male and female - > 5.000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: dl-α-
TocopherolacetateCarcinogenicity
No data available
Reproductive toxicity
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: dl-α-
TocopherolacetateCarcinogenicity
No data available
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting propertiesProduct:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12.1 Toxicity
Toxicity to fish flow-through test LC50 - Oncorhynchus mykiss (rainbow trout) - > 10 mg/l - 96 h (OECD Test Guideline 203)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 23,53 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - > 25,8 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol static test NOEC - Pseudokirchneriella subcapitata (green algae) - 25,8 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Toxicity to bacteria static test EC50 - Pseudomonas putida - > 10.000 mg/l - 0,5 h (DIN 38412)
Remarks: The value is given in analogy to the following substances: α-Tocopheryl acetate
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 23,53 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - > 25,8 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol static test NOEC - Pseudokirchneriella subcapitata (green algae) - 25,8 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: (+)-α-Tocopherol
Toxicity to bacteria static test EC50 - Pseudomonas putida - > 10.000 mg/l - 0,5 h (DIN 38412)
Remarks: The value is given in analogy to the following substances: α-Tocopheryl acetate
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 20 % - Not readily biodegradable.
(OECD Test Guideline 301F)
Remarks: The value is given in analogy to the following substances:
DL-α-Tocopherol
Result: 20 % - Not readily biodegradable.
(OECD Test Guideline 301F)
Remarks: The value is given in analogy to the following substances:
DL-α-Tocopherol
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Offer surplus and non-recyclable solutions to a licensed disposal company.
Dispose of as unused product.
14.1 UN number
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA: no
IMDG Marine pollutant: no
IATA: no
14.6 Special precautions for user
No data available
Further information: Not classified as dangerous in the meaning of transport regulations.
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
1907/2006.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways
ADR - Agreement concerning the International Carriage ofDangerous Goods by Road
AIIC - Australian Inventory of Industrial Chemicals
ASTM -American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen,Mutagen or Reproductive Toxicant
DIN - Standard of the German Institute forStandardisation
DSL - Domestic Substances List (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS -Emergency Schedule
ENCS - Existing and New Chemical Substances (Japan)
ErCx -Concentration associated with x% growth rate response
GHS - Globally HarmonizedSystem
GLP - Good Laboratory Practice
IARC - International Agency for Research onCancer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 - Half maximal inhibitory concentration
ICAO - International Civil Aviation Organization
IECSC - Inventory of Existing Chemical Substances in China
IMDG - InternationalMaritime Dangerous Goods
IMO - International Maritime Organization
ISHL - IndustrialSafety and Health Law (Japan)
ISO - International Organisation for Standardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concentration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pollution from Ships
n.o.s. -Not Otherwise Specified
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Effect Level
NOELR - No Observable Effect LoadingRate
NZIoC - New Zealand Inventory of Chemicals
OECD - Organization for EconomicCo-operation and Development
OPPTS - Office of Chemical Safety and PollutionPrevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - PhilippinesInventory of Chemicals and Chemical Substances
(Q)SAR - (Quantitative) StructureActivity Relationship
REACH - Regulation (EC) No 1907/2006 of the EuropeanParliament and of the Council concerning the Registration, Evaluation, Authorisation andRestriction of Chemicals
RID - Regulations concerning the International Carriage ofDangerous Goods by Rail
SADT - Self-Accelerating Decomposition Temperature
SDS -Safety Data Sheet
TCSI - Taiwan Chemical Substance Inventory
TECI - ThailandExisting Chemicals Inventory
TSCA - Toxic Substances Control Act (United States)
UN - United Nations
UNRTDG - United Nations Recommendations on the Transport ofDangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
ADR - Agreement concerning the International Carriage ofDangerous Goods by Road
AIIC - Australian Inventory of Industrial Chemicals
ASTM -American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen,Mutagen or Reproductive Toxicant
DIN - Standard of the German Institute forStandardisation
DSL - Domestic Substances List (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS -Emergency Schedule
ENCS - Existing and New Chemical Substances (Japan)
ErCx -Concentration associated with x% growth rate response
GHS - Globally HarmonizedSystem
GLP - Good Laboratory Practice
IARC - International Agency for Research onCancer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 - Half maximal inhibitory concentration
ICAO - International Civil Aviation Organization
IECSC - Inventory of Existing Chemical Substances in China
IMDG - InternationalMaritime Dangerous Goods
IMO - International Maritime Organization
ISHL - IndustrialSafety and Health Law (Japan)
ISO - International Organisation for Standardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concentration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pollution from Ships
n.o.s. -Not Otherwise Specified
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Effect Level
NOELR - No Observable Effect LoadingRate
NZIoC - New Zealand Inventory of Chemicals
OECD - Organization for EconomicCo-operation and Development
OPPTS - Office of Chemical Safety and PollutionPrevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - PhilippinesInventory of Chemicals and Chemical Substances
(Q)SAR - (Quantitative) StructureActivity Relationship
REACH - Regulation (EC) No 1907/2006 of the EuropeanParliament and of the Council concerning the Registration, Evaluation, Authorisation andRestriction of Chemicals
RID - Regulations concerning the International Carriage ofDangerous Goods by Rail
SADT - Self-Accelerating Decomposition Temperature
SDS -Safety Data Sheet
TCSI - Taiwan Chemical Substance Inventory
TECI - ThailandExisting Chemicals Inventory
TSCA - Toxic Substances Control Act (United States)
UN - United Nations
UNRTDG - United Nations Recommendations on the Transport ofDangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.