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Technical Data Sheet CB5083

Compound Information
Product Name: CB5083
CAS No.: 1542705-92-9
Molecular Formula: C24H23N5O2
Molecular Weight: 413.47
Storage: Store at -20°C
Revision Date: 2026-04-27
Analytical Information
Tests Specifications
Description CB-5083 is a first-in-class, potent and selective, orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM.
IUPAC Name 1- [7,8- Dihydro- 4- [(phenylmethyl)amino]- 5H- pyrano[4,3- d]pyrimidin- 2- yl]- 2- methyl- 1H- indole- 4- carboxamide
Form solid
Color White to light yellow
Solubility insoluble in H2O; ≥20.65 mg/mL in DMSO; ≥4.4 mg/mL in EtOH
HPLC Shows 98.4% purity
NMR Pass test
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