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Technical Data Sheet Entrectinib
Compound Information
Product Name:
Entrectinib
CAS No.:
1108743-60-7
Molecular Formula:
C31H34F2N6O2
Molecular Weight:
560.64
Storage:
Powder -20°C 3 years; 4°C 2 years
In solvent -80°C 6 months; -20°C 1 month
In solvent -80°C 6 months; -20°C 1 month
Revision Date:
2026-04-15
Analytical Information
| Tests | Specifications |
|---|---|
| Description | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. |
| Form | solid |
| Color | Off-white to light yellow |
| Solubility | ≥28.05 mg/mL in DMSO; insoluble in H2O; ≥9.82 mg/mL in EtOH with ultrasonic |
| Purity | 99.81% |
| MS | Pass test |
| ¹H NMR | Pass test |
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